ArticleNature communications2025
Downstream metabolites of (+)-cis-12-oxo-phytodienoic acid function as noncanonical bioactive jasmonates in Arabidopsis thaliana.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Sulfur metabolism-dependent retrograde signaling for oxidative stress acclimation.Journal of experimental botany · 2026Review
- Molecular Mechanisms and Network Integration of Oxylipin Signaling in Plant Abiotic Stress Tolerance.International journal of molecular sciences · 2026Review
- (3R, 7S)-11-hydroxy-jasmonic acid is a major oxidative shunt product of jasmonic acid catabolism in Arabidopsis thaliana.Nature communications · 2026Article
- Regulatory Role of Jasmonate Signaling in Dark-, Drought-, and Salt-Induced Leaf Senescence.International journal of molecular sciences · 2026Review
- HY5 integrates light and electrical signaling to trigger a jasmonate burst for nematode defense in tomato.Nature communications · 2025Article
- Transcriptomics and trans-organellar complementation reveal limited signaling of 12-cis-oxo-phytodienoic acid during early wound response in Arabidopsis.Nature communications · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
(+)-cis-12-oxo-phytodienoic acid (cis-OPDA) is a biosynthetic precursor of the plant hormone (+)-7-iso-Jasmonoyl-L-isoleucine (JA-Ile). It was proposed as an endogenous chemical signal independent of the JA-Ile receptor COI1-JAZ in Arabidopsis thaliana. The bioactive form of cis-OPDA that induces COI1-JAZ-independent gene expression remains unknown. Here we demonstrate that the downstream metabolites of cis-OPDA, especially tetranor-cis-OPDA (tn-cis-OPDA) and 7-iso-4,5-didehydro-JA (4,5-ddh-JA), upregulate the expression of the OPDA marker genes such as ZAT10 and ERF5. These downstream metabolites function independently of the JA-Ile-COI1-JAZ-MYCs canonical jasmonate signaling module, and their electrophilic α, β-unsaturated carbonyl functionalities are essential for their bioactivity. These results raise a possibility that the downstream metabolites of cis-OPDA would function as endogenous chemical signal in A. thaliana.
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Registered trials
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