ArticleScientific reports2025
Hierarchical metal exposure in umbilical cord blood in relation to oxidative stress and AMPK/NF-κB signaling in preterm membrane rupture.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Vaccinations for Expecting Mothers to Improve Pregnancy Care in Middle Tennessee.Pathogens (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
To investigate the correlation between metal element levels, AMPK(AMP-activated protein kinase) and NF-κBp65(Nuclear factor kappa-B p65) and PPROM(preterm premature rupture of membranes). 20cases of PPROM,33cases of TPROM(Term premature rupture of membranes), and 33cases of nPROM were selected, totaling 86patients.Metal element content in umbilical cord blood serum was measured using ICP-MS(Inductively Coupled Plasma Mass Spectrometry).HE(Hematoxylin-eosin) staining was utilized to observe histological changes in the placentas of the three groups.IHC(Immunohistochemistry) and Western Blot were applied to detect the expression levels of AMPKα and NF-κBp65 in the placental tissues. The levels of Mg, Fe, and Mo in the PPROM group were significantly lower than those in the nPROM group and TPROM group(P<0.05).The levels of Al, Cr, and As in the PPROM group were significantly higher than those of the TPROM group(P<0.05).The incidence of chorioamnionitis in the PPROM group was higher than that in the TPROM group and nPROM group(P < 0.05).The positive expression rates of AMPKα and NF-κBp65 in the placental tissues of the PPROM group were lower than those of the TPROM group and the nPROM group(P < 0.05). Exposure to Al, Cr, As during pregnancy or a deficiency in Mg, Fe, Mo may be among the risk factors for PPROM.The decreased expression of AMPK and NF-κBp65 in placental tissue may be one of the mechanisms contributing to the occurrence of PPROM.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.