Evidence map›Paper›PMID 40691203›Full record

ArticleScientific reports2025

The mechanism of parvalbumin interneurons regulating glutamatergic neurons involvement in stress induced anxiety in the basolateral amygdala of male mice.

Xiaorui Su, Xuetong Dong, Chao-Long Lu, Minglong Zhang, Yaping Li, Han Xiao, Jian Wang, Yufei Sun, Bin Cong, Songjun Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Parvalbumin interneurons under stress: converging mechanisms of vulnerability.The international journal of neuropsychopharmacology · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaorui SuHebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, College of Forensic Medicine, Hebei Medical University, No. 361 Zhong Shan Road, Shijiazhuang, Hebei, China.
Xuetong DongHebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, College of Forensic Medicine, Hebei Medical University, No. 361 Zhong Shan Road, Shijiazhuang, Hebei, China.
Chao-Long LuHebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, College of Forensic Medicine, Hebei Medical University, No. 361 Zhong Shan Road, Shijiazhuang, Hebei, China.
Minglong ZhangDepartment of Genetics, College of Basic Medicine, Qiqihar Medical University, No. 333 Bukui South Street, Qiqihar, 161006, Heilongjiang, China.
Yaping LiHebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, College of Forensic Medicine, Hebei Medical University, No. 361 Zhong Shan Road, Shijiazhuang, Hebei, China.
Han XiaoHebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, College of Forensic Medicine, Hebei Medical University, No. 361 Zhong Shan Road, Shijiazhuang, Hebei, China.
Jian WangHebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, College of Forensic Medicine, Hebei Medical University, No. 361 Zhong Shan Road, Shijiazhuang, Hebei, China.
Yufei SunHebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, College of Forensic Medicine, Hebei Medical University, No. 361 Zhong Shan Road, Shijiazhuang, Hebei, China.
Bin CongHebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, College of Forensic Medicine, Hebei Medical University, No. 361 Zhong Shan Road, Shijiazhuang, Hebei, China. cong6406@hebmu.edu.cn.
Songjun WangHebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, College of Forensic Medicine, Hebei Medical University, No. 361 Zhong Shan Road, Shijiazhuang, Hebei, China. 17800584@hebmu.edu.cn.

Funding

Key Program of National Natural Science Foundation of China 82130055Major Program of National Natural Science Foundation of China 82293651Natural Science Foundation of Hebei Province H2024206002Open Project of the Key Laboratory of Forensic Pathology of the Ministry of Public Security GAFYBL202303Science and Technology Research Project of Colleges and Universities in Hebei Province ZD2022132Shanghai Key Laboratory of Forensic Medicine and Key Laboratory of Forensic Science, Ministry of Justice KF202404
6 · The paper itself

Abstract

Modern life's fast-paced and the unexpected conditions contribute to escalating stress levels, often leading to anxiety disorders and posing significant challenges to physical and mental health. In judicial practice, the parties often suffer from anxiety disorder under the great stress. However, the precise mechanisms underlying stress-induced anxiety disorders remain incompletely understood. This study aims to explore the neural mechanisms by which stress-induced imbalances in the basolateral amygdala (BLA) parvalbumin interneurons (PV-INs) and glutamatergic neurons lead to anxiety. This study used behavioral analysis, morphology, patch clamp electrophysiology, and viral interference techniques to detect the number of BLA PV-INs and glutamatergic neurons, as well as the excitability of glutamatergic neurons. Results demonstrated that acute and chronic stress adversely affect PV-INs in the BLA, diminishing their numbers and resulting in glutamatergic neurons disinhibition, thereby enhancing glutamatergic neurons excitability and precipitating anxiety behaviour. The anxiety disorder can be effectively improved by activating PV-INs. This study reveals the mechanism of internal amygdala PV-INs regulation leading to anxiety disorders under acute and chronic stress.

Indexed as

AnxietyBasolateral Nuclear ComplexGlutamic AcidInterneuronsNeuronsParvalbuminsStress, PsychologicalAnimalsMaleMiceMice, Inbred C57BLGlutamic AcidParvalbuminsAcute stressChronic stressGlutamatergic neuronsPV-INsStress induced anxiety

Identifiers

PMID40691203
PMCPMC12280162

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.