Evidence map›Paper›PMID 40691132›Full record

ArticleNature communications2025

Transcriptomic decoding of surface-based imaging phenotypes and its application to pharmacotranscriptomics.

Christine Ecker, Charlotte M Pretzsch, Johanna Leyhausen, Lisa M Berg, Caroline Gurr, Hanna Seelemeyer, Grainne McAlonan, Nicolaas A Puts, Eva Loth, Flavio Dell'Aqua and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Autism and Cortical Thickness Deviation From Neurotypical Controls: Evidence for a Spatial Association With Serotonin Receptors.Autism research : official journal of the International Society for Autism Research · 2026
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Christine EckerDepartment of Child and Adolescent Psychiatry, University Hospital of the Goethe University, Frankfurt am Main, Germany. ecker@med.uni-frankfurt.de.
Charlotte M PretzschDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-2761-6628
Johanna LeyhausenDepartment of Child and Adolescent Psychiatry, University Hospital of the Goethe University, Frankfurt am Main, Germany.ORCID http://orcid.org/0000-0003-1438-4001
Lisa M BergDepartment of Child and Adolescent Psychiatry, University Hospital of the Goethe University, Frankfurt am Main, Germany.
Caroline GurrDepartment of Child and Adolescent Psychiatry, University Hospital of the Goethe University, Frankfurt am Main, Germany.
Hanna SeelemeyerDepartment of Child and Adolescent Psychiatry, University Hospital of the Goethe University, Frankfurt am Main, Germany.
Grainne McAlonanDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-4466-2343
Nicolaas A PutsDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0003-1024-1927
Eva LothDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0001-9458-9167
Flavio Dell'AquaDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0001-5313-5476
Luke MasonDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Tony CharmanDepartment of Psychology, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0003-1993-6549
Bethany OakleyDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Thomas BourgeronHuman Genetics and Cognitive Functions Unit, Institut Pasteur, University de Paris, Paris, France.
Christian BeckmannDepartment of Medical Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands.
Jan K BuitelaarDepartment of Medical Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands.ORCID http://orcid.org/0000-0001-8288-7757
Celso ArangoDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health Hospital General Univesitario Gregorio Maranon, and School of Medicine, Universidad Complutense de Madrid, CIBERSAM, Madrid, Spain.ORCID http://orcid.org/0000-0003-3382-4754
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany; German Center for Mental Health (DZPG), partner site Mannheim-Heidelberg-Ulm, Ulm, Germany.ORCID http://orcid.org/0000-0003-4595-1144
Andreas G ChiocchettiDepartment of Child and Adolescent Psychiatry, University Hospital of the Goethe University, Frankfurt am Main, Germany.
Christine M FreitagDepartment of Child and Adolescent Psychiatry, University Hospital of the Goethe University, Frankfurt am Main, Germany.ORCID http://orcid.org/0000-0001-9676-4782
Elke HattingenInstitute for Neuroradiology, University Hospital of the Goethe University, Frankfurt am Main, Germany.
Dilja Krueger-BurgInstitute of Anatomy, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.ORCID http://orcid.org/0000-0001-5597-6287
Michael J SchmeisserInstitute of Anatomy, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
Jonathan ReppleCooperative Brain Imaging Center (CoBIC), Goethe University Frankfurt, Frankfurt am Main, Germany.
Andreas ReifDepartment of Psychiatry, Psychosomatics, and Psychotherapy, University Hospital of the Goethe University Frankfurt, Frankfurt am Main, Germany.
Declan G MurphyDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-6664-7451

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Imaging transcriptomics has become a power tool for linking imaging-derived phenotypes (IDPs) to genomic mechanisms. Yet, its potential for guiding CNS drug discovery remains underexplored. Here, utilizing spatially-dense representations of the human brain transcriptome, we present an analytical framework for the transcriptomic decoding of high-resolution surface-based neuroimaging patterns, and for linking IDPs to the transcriptomic landscape of complex neurotransmission systems in vivo. Leveraging publicly available Positron Emission Tomography (PET) data, we initially validated our approach against molecular targets with a high correspondence between gene expression and protein binding. Subsequently, we used the cortical gene expression profiles of candidate genes to dissect two discrete classes of GABA

Indexed as

BrainNeuroimagingTranscriptomeFemaleGene Expression ProfilingHumansMalePhenotypePositron-Emission TomographyReceptors, GABA-AReceptors, GABA-A

Identifiers

PMID40691132
PMCPMC12279933

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.