Evidence map›Paper›PMID 40691045›Full record

ArticleAmerican journal of physiology. Renal physiology2025

Macula densa nitric oxide synthase 1β restoration by kidney alkalization enhances renal graft outcomes.

Colby L Parris, Catherine Liu, Alka Rani, Minh H Tran, Minghua Li, Carlos Esquivel, Andrea Oropeza, Lei Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Colby L ParrisDepartment of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, Florida, United States.
Catherine LiuDepartment of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, Florida, United States.ORCID 0000-0003-0990-5458
Alka RaniDepartment of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, Florida, United States.
Minh H TranDepartment of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, Florida, United States.
Minghua LiDepartment of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, Florida, United States.
Carlos EsquivelDepartment of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, Florida, United States.
Andrea OropezaDepartment of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, Florida, United States.
Lei WangDepartment of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, Florida, United States.ORCID 0000-0002-0181-0043

Funding

Tubuloglomerular feedback response in AKI to CKD transitionR01DK134028 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI LIU, RUISHENG · 2022 to 2025
$2.6M
Protection of donor kidney and transplanted graft function by modulating Na/K ATPase activityR01DK138092 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI WEI CHEN, RUISHENG LIU · 2024 to 2026
$2.0M
Macula densa NOS1 and transplanted renal graft functionR01DK122050 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI WANG, LEI · 2020 to 2024
$1.6M
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK122050HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK138092NIDDK NIH HHS R01 DK122050NIDDK NIH HHS R01 DK134028NIDDK NIH HHS R01 DK138092
6 · The paper itself

Abstract

Ischemia-reperfusion injury (IRI) remains a critical challenge to the survival of kidney transplantation (KTX) graft, with no effective prevention or treatment strategies currently available. Neuronal nitric oxide synthase 1β (NOS1β), the predominant splice variant of NOS1 and the main source of NO in the macula densa (MD), mediates tubuloglomerular feedback and regulates glomerular filtration rates. NOS1β activity in the MD is influenced by renal pH; however, the role of pH-dependent regulation of NOS1β in mitigating IRI and protecting transplanted kidney graft function remains unclear. To explore this, C57BL/6J mice were given oral sodium bicarbonate (NaHCO

Indexed as

Graft SurvivalKidneyKidney TransplantationNitric Oxide Synthase Type IReperfusion InjurySodium BicarbonateAnimalsDisease Models, AnimalHydrogen-Ion ConcentrationMaleMiceMice, Inbred C57BLMice, KnockoutNitric OxideNitric OxideNitric Oxide Synthase Type INos1 protein, mouseSodium Bicarbonatekidney graft functionNaHCO3nitric oxide synthase 1βrenal pH

Identifiers

PMID40691045
PMCPMC12337523

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.