Observational studyThe Journal of clinical endocrinology and metabolism2026
Parathyroidectomy Restores Muscle Strength and Transcriptome in Individuals With Primary Hyperparathyroidism.
Observational study in The Journal of clinical endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Effects of Parathyroidectomy on Muscle Mass, Strength, and Physical Function in Uremia-Associated Secondary Hyperparathyroidism.Healthcare (Basel, Switzerland) · 2026Article
- Neuropsychiatric manifestations of primary hyperparathyroidism.Wiener klinische Wochenschrift · 2026Review
- The impact of hyperparathyroidism on skeletal muscle pathophysiology and physical function.Endocrine connections · 2026Review
- A Modern-Day Captain Charles Martell: Catastrophic Skeletal Manifestations of Primary Hyperparathyroidism.Case reports in endocrinology · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
contextPrimary hyperparathyroidism leads to hypercalcemia and muscle dysfunction. Muscle weakness is associated with increased morbidity and mortality but is overlooked in surgical treatment guidelines. While parathyroidectomy is the only curative treatment, its effects on skeletal muscle strength and molecular remodeling remain underexplored.
objectiveDetermining functional and molecular changes in skeletal muscle before and after parathyroidectomy.
methodsA prospective observational study was conducted in the spring and fall of 2023. Patients underwent surgery at the Endocrine and Sarcoma unit at the Karolinska University Hospital in Stockholm, Sweden. A total of 21 postmenopausal women with primary hyperparathyroidism planned for surgery were included, whereof 15 completed the study protocol. Participants had no disabling comorbidities. Muscle function tests, muscle biopsies, MRI, and biochemical panels were analyzed before and after parathyroidectomy. Muscle composition of m. vastus lateralis was tested with MRI and transcriptomic analysis of muscle biopsies. Leg strength was evaluated with timed stands test and peak torque tests. Activity level was estimated from questionnaires.
resultsParathyroidectomy normalized calcium levels (P < .001) and improved muscle strength (P < .005). Muscle volume increased (P = .023) and fat fraction was reduced (P = .013), without changes in physical activity levels. Transcriptomic analysis identified 981 differentially expressed genes postsurgery, enriched in pathways mirroring exercise-induced adaptations.
conclusionThese findings highlight the impact of parathyroidectomy on skeletal muscle function and suggest that muscle assessments should be included in surgical referral criteria to address age-related muscle decline and improve long-term outcomes.
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