Evidence map›Paper›PMID 40690800›Full record

ArticleJournal of neurosurgery. Case lessons2025

MR-guided focused ultrasound thalamotomy in a patient with thrombocytopenia: illustrative case.

Rafael Buongermini, Oliver Bichsel, Franziska Anna Schmidt, Mohammed Mehdi Hajiabadi, Jorge Cabrera-Montes, Matthew C Mueller, Andrew Yang, Anuj Bhatia, Jürgen Germann, Alexandre Boutet and 1 more

Abstract read
In one paragraph

Article in Journal of neurosurgery. Case lessons, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rafael BuongerminiToronto Western Hospital-University Health Network, Toronto, Ontario, Canada.
Oliver BichselToronto Western Hospital-University Health Network, Toronto, Ontario, Canada.
Franziska Anna SchmidtToronto Western Hospital-University Health Network, Toronto, Ontario, Canada.
Mohammed Mehdi HajiabadiToronto Western Hospital-University Health Network, Toronto, Ontario, Canada.ORCID 0000-0003-4346-3657
Jorge Cabrera-MontesDepartment of Neurosurgery, Hospital Universitario Fundación Jiménez Díaz, Madrid, Comunidad de Madrid, Spain.ORCID 0000-0002-1988-8682
Matthew C MuellerTemerty Faculty of Medicine, University of Toronto, Ontario, Canada.ORCID 0000-0002-7948-5180
Andrew YangTemerty Faculty of Medicine, University of Toronto, Ontario, Canada.
Anuj BhatiaToronto Western Hospital-University Health Network, Toronto, Ontario, Canada.
Jürgen GermannToronto Western Hospital-University Health Network, Toronto, Ontario, Canada.
Alexandre BoutetToronto Western Hospital-University Health Network, Toronto, Ontario, Canada.
Andres M LozanoToronto Western Hospital-University Health Network, Toronto, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMR-guided focused ultrasound (MRgFUS) thalamotomy is a relatively novel technique used to treat essential tremor (ET) and tremor-dominant Parkinson's disease. It is thought to be a safer alternative to other treatments, with no reported cases of major intracranial bleeding to date. However, experience with patients at increased risk of hemorrhage is still limited. OBSERVATIONS: The authors present the case of a successfully treated ET patient with thrombocytopenia who experienced no postprocedural complications, detailing the surgical optimization strategy used. They conducted a systematic review of the literature, focusing on articles addressing MRgFUS in patients with known coagulation disorders. The Embase, Scopus, and MEDLINE databases were queried from their inception to August 20, 2024. Of the 973 screened abstracts, 2 relevant studies were identified. The first study included 40 patients undergoing MRgFUS without interruption of antiplatelet or anticoagulant therapy, while the second was a case report of a patient with von Willebrand disease. Both studies reported satisfactory safety profiles, with no increased incidence of hemorrhagic or other complications. LESSONS: Although evidence is limited due to the small number of studies and cases, these findings suggest that MRgFUS, with appropriate periprocedural optimization, represents a viable option for patients at heightened risk of intracranial hemorrhage. https://thejns.org/doi/10.3171/CASE2525.

Indexed as

coagulation disorderfunctional neurosurgeryMR-guided focused ultrasoundthalamotomythrombocytopenia

Identifiers

PMID40690800
PMCPMC12278958

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.