Observational studyJournal of radiation research2025
The impact of relationship between tumor volume and radiation dose on pain relief: are higher doses needed for larger tumors?
Observational study in Journal of radiation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The influences of tumor volume and total radiation dose on pain relief outcomes have not been fully investigated. We investigated potential correlations between gross tumor volume (GTV), biologically effective dose (BED) and pain relief in patients receiving radiation therapy (RT) for painful tumors. As a secondary analysis of a three-center prospective observational study of 302 patients who received RT for painful tumors, patients treated at an academic hospital were analyzed. We used the Brief Pain Inventory short form to evaluate pain intensity and interference in patients' lives. We collected the Brief Pain Inventory and analgesic data at baseline and 1, 2, 3, 6, 9 and 12 months after the start of RT. Pain responses were assessed using the International Consensus Endpoint. The Fine and Gray models were used for univariable and multivariable analyses, to estimate the impact of clinical factors on pain response and pain progression. In total, 153 (59%) of the 258 patients experienced a pain response, and 45 (17%) patients experienced pain progression. In the univariable and multivariable analyses, GTV and BED did not significantly associate with pain response or pain progression. Furthermore, no significant interaction between GTV and BED was reported in terms of pain response or pain progression after adjusting for covariates. The impact of BED on pain response and pain progression did not vary according to the GTV.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.