Evidence map›Paper›PMID 40690364›Full record

ArticleCell reports2025

PPM1M, an LRRK2-counteracting, phosphoRab12-preferring phosphatase with a potential link to Parkinson's disease.

Claire Y Chiang, Neringa Pratuseviciute, Yu-En Lin, Ayan Adhikari, Wondwossen M Yeshaw, Chloe Flitton, Pemba L Sherpa, Francesca Tonelli, Irena Rektorova, Timothy Lynch and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors.

Claire Y ChiangDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.
Neringa PratuseviciuteMRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, UK.
Yu-En LinDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.
Ayan AdhikariDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.
Wondwossen M YeshawDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.
Chloe FlittonAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA; MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, UK.
Pemba L SherpaDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.
Francesca TonelliAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA; MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, UK.
Irena RektorovaSchool of Medicine and St Anne's Hospital, 1st Department of Neurology, Pekarska 53, Brno, Czech Republic.
Timothy LynchDepartment of Neurology, Dublin Neurological Institute, Dublin, Ireland.
Joanna SiudaŚląski Uniwersytet Medyczny w Katowicach, Katowice, Poland.
Monika Rudzińska-BarDepartment of Neurology, Andrzej Frycz Modrzewski University, Krakow, Poland.
Oleksandr PulykWladyslaw Bieganski Collegium Medicum Jan Długosz University, Częstochowa, Poland.
Peter BauerCENTOGENE GmbH, Rostock, Germany.
Christian BeetzCENTOGENE GmbH, Rostock, Germany.
Dennis W DicksonMayo Clinic Florida, Department of Neuroscience, Jacksonville, FL 32224, USA.
Owen A RossMayo Clinic Florida, Department of Neuroscience, Jacksonville, FL 32224, USA.
Zbigniew K WszolekMayo Clinic Florida, Department of Neuroscience, Jacksonville, FL 32224, USA.
Global Parkinson’s Genetics Program (GP2)
Zih-Hua FangGerman Center for Neurodegenerative Diseases, DZNE, Tübingen, Germany.
Christine KleinInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Alexander ZimprichDepartment of Neurology, Medical University of Vienna, Vienna, Austria.
Dario R AlessiAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA; MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, UK.
Esther M SammlerAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA; MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, UK.
Suzanne R PfefferDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. Electronic address: pfeffer@stanford.edu.

Funding

Supplement to Enhance Wellness and Resiliency in the Graduate EnvironmentT32GM007276 · NIGMS · STANFORD UNIVERSITY · PI MORRISON, ASHBY J. · 1985 to 2023
$32.9M
NIGMS NIH HHS T32 GM007276
6 · The paper itself

Abstract

Leucine-rich repeat kinase 2 (LRRK2) phosphorylates a subset of Rab GTPases that regulate receptor trafficking, and LRRK2-activating mutations are linked to Parkinson's disease. Rab phosphorylation is a transient event that can be reversed by phosphatases, including protein phosphatase, Mg2

Indexed as

Leucine-Rich Repeat Serine-Threonine Protein Kinase-2Parkinson DiseaseProtein Phosphatase 2Crab GTP-Binding ProteinsAnimalsHEK293 CellsHumansMiceMice, KnockoutMutationPhosphorylationLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Protein Phosphatase 2Crab GTP-Binding ProteinsCP: Cell biologyCP: NeuroscienceLRRK2 kinaseParkinson’s diseasephosphataseprimary ciliaRab GTPase

Identifiers

PMID40690364
PMCPMC12462683

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.