ArticleAnalytical chemistry2025
Gas Phase Separation of Modified Peptides for Activity-Based Protein Profiling.
Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Profiling the reactivity of the proteome with amino-acid level resolution requires the identification and quantification of reacted peptides in the presence of abundant unmodified peptides. Affinity-based approaches use solid sorbents such as streptavidin beads to enrich modified peptides in a solution but are step-intensive and suffer from analyte losses. Here, we describe timShift, a gas phase, in-spectrometer approach for enhanced reactive amino acid profiling, which exploits modification-induced alteration of peptide physical properties. A dicationic, aerodynamic, cysteine-reactive reagent increases the ion mobility of labeled peptides, physically separating them from unmodified 1
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