ArticleGeneral thoracic and cardiovascular surgery2026
Importance of the ratio of surgical margin to nodule size in pulmonary metastasectomy for colorectal carcinoma.
Article in General thoracic and cardiovascular surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPulmonary metastasectomy (PM) is a survival-enhancing treatment in the multimodal management of metastatic colorectal cancer (CRC). Given the high recurrence rates, we hypothesized that the adequacy of the surgical margin relative to nodule size might have prognostic value. This study aimed to analyze clinical characteristics and identify prognostic factors for disease-free survival (DFS) and overall survival (OS) in patients who underwent PM for CRC.
methodsWe retrospectively reviewed 105 patients who underwent PM for CRC metastases between January 2010 and December 2023. Survival outcomes were analyzed using Kaplan-Meier and Cox regression models. ROC analysis was used to determine the optimal cut-off value for the ratio of surgical margin (SM) to nodule size (NS).
resultsThe optimal cut-off value for SM/NS was 0.61 for DFS (sensitivity: 80.5%, specificity: 57%, (95% CI 0.67-0.86; p < 0.001) and 0.59 (95% CI 0.61-0.82; p < 0.001) with a sensitivity of 83.7% and specificity of 57.1% for OS. Univariate analysis showed that CEA level, disease-free interval (DFI), and NS were significantly associated with both DFS and OS. SM/NS was also significant for both outcomes (p < 0.001 and p = 0.001). Multivariate analysis confirmed that CEA, DFI, NS, and SM/NS were independent prognostic factors for DFS and OS (all p < 0.05).
conclusionsSM/NS ratio may be a reliable prognostic factor in PM for CRC. A ratio of ≤ 0.6 was associated with poorer survival outcomes and could be a more consistent indicator than nodule size or margin width alone.
Indexed as
Identifiers
40690165What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.