Evidence map›Paper›PMID 40690066›Full record

ArticleHead and neck pathology2025

A Novel Odontogenic Carcinoma with CDK4/MDM2 Co-Amplification: Expanding the Phenotypic Spectrum of Malignant Odontogenic Entities.

Mengxin Ren, Jiaxin Yang, Yanan Sun, Shaodong Yang, Li Wang, Jie Cheng, Hui Zhang, Shilu Tu, Tian Xu, Xiaohong Yang and 1 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Head and neck pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mengxin Ren *State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Luoyu Road 237, Wuhan, 430079, China.
Jiaxin Yang *Depatment of Oral Pathology, School and hospital of Stomatology, Wuhan University, Wuhan, China.
Yanan SunState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Luoyu Road 237, Wuhan, 430079, China.
Shaodong YangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Luoyu Road 237, Wuhan, 430079, China.
Li WangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Luoyu Road 237, Wuhan, 430079, China.
Jie ChengDepatment of Oral Pathology, School and hospital of Stomatology, Wuhan University, Wuhan, China.
Hui ZhangDepatment of Oral Pathology, School and hospital of Stomatology, Wuhan University, Wuhan, China.
Shilu TuDepatment of Oral Pathology, School and hospital of Stomatology, Wuhan University, Wuhan, China.
Tian XuDepatment of Oral Pathology, School and hospital of Stomatology, Wuhan University, Wuhan, China.
Xiaohong YangUltrasound Diagnosis Department, Maternal and Child Health Hospital of Hubei Province, Wuhan, China. yangxiaohong123@163.com.
Jiali ZhangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Luoyu Road 237, Wuhan, 430079, China. jiali_zhang@whu.edu.cn.ORCID http://orcid.org/0000-0003-0965-3027

Funding

National Natural Science Foundation of China 82273201
6 · The paper itself

Abstract

CDK4/MDM2 co-amplification, a molecular aberration predominantly observed in sarcomas, has not been previously reported in odontogenic neoplasms. We present the first documented case of odontogenic carcinoma with CDK4/MDM2 co-amplification. The tumor exhibited distinctive histologic features including irregular luminal/cleft structures lined by monolayer epithelium over whorled stromal cores. This case expands both the histopathological spectrum and molecular landscape of odontogenic carcinomas. Furthermore, our findings support routine molecular profiling for rare odontogenic malignancies to improve classification and suggest potential theraputic targets.

Indexed as

Cyclin-Dependent Kinase 4Odontogenic TumorsProto-Oncogene Proteins c-mdm2Gene AmplificationHumansCDK4 protein, humanCyclin-Dependent Kinase 4MDM2 protein, humanProto-Oncogene Proteins c-mdm2CDK4/MDM2 co-amplificationNGSOdontogenic Carcinoma

Identifiers

PMID40690066
PMCPMC12279649

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.