Evidence map›Paper›PMID 40690063›Full record

ReviewNeurochemical research2025

The Multifaceted Role of P2X7R in Microglia and Astrocytes.

Martina Bedetta, Paola Pizzo, Annamaria Lia

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurochemical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Martina BedettaDepartment of Biomedical Sciences, University of Padova, Padua, Italy.
Paola PizzoDepartment of Biomedical Sciences, University of Padova, Padua, Italy. paola.pizzo@unipd.it.
Annamaria LiaDepartment of Biomedical Sciences, University of Padova, Padua, Italy. annamaria.lia@unipd.it.

Funding

Alzheimer's Association E2A-23-1148250Italian Ministry of University and Scientific Research PRIN2022943TH9
6 · The paper itself

Abstract

The purinergic P2X7 receptor (P2X7R) is a unique ATP-gated ion channel that requires unusually high concentrations of extracellular ATP (eATP) for activation, making it a sensor of cellular stress and injury in the central nervous system. This review provides a comprehensive overview of P2X7R expression and function in glial cells, with a particular focus on microglia and astrocytes. We first outline the molecular characteristics of P2X7R and its distribution in brain cell types. In microglia, P2X7R regulates a broad spectrum of processes, including phagocytosis, autophagy, proliferation, and ultimately cell death, underscoring its dual role in neuroprotection and neurotoxicity. In astrocytes, P2X7R contributes to gliotransmission and inflammatory signaling, influencing neuronal excitability and synaptic function. We further explore the role of P2X7R in the context of both Alzheimer's disease and epilepsy, where a dysregulated eATP-P2X7R signaling axis exacerbates neuroinflammation and glial dysfunction. Understanding the cell-specific roles of P2X7R in physiology and pathology provides new insights into glial biology and highlights its potential as a therapeutic target in brain diseases.

Indexed as

AstrocytesMicrogliaReceptors, Purinergic P2X7Adenosine TriphosphateAnimalsHumansSignal TransductionAdenosine TriphosphateReceptors, Purinergic P2X7eATPGliaInflammationP2X7R

Identifiers

PMID40690063
PMCPMC12279596

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.