ArticleMolecular biology reports2025
Effects of safranal on antidiabetic and endothelial dysfunction in streptozotocin-induced diabetic rats.
Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Targeting pathological chemokines in CVD: the role of saffron on CCL2 and CXCL8.Molecular biology reports · 2026Review
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectivesDiabetes Mellitus (DM) is a common metabolic disorder that requires ongoing treatment. While oral hypoglycemic drugs are commonly used, they do not provide a permanent cure and can have adverse effects. In order to find more effective treatments with fewer adverse effects, researchers are focusing on herbal sources. Saffron extract, known for its therapeutic and aromatic qualities, has shown promising antidiabetic effects in numerous in vivo and clinical studies. This study aims to explore the antidiabetic potential of safranal, an active constituent of saffron, with a specific focus on its ability to protect against diabetes-related endothelial damage.
methodsIn this study, five groups of four-month-old male Wistar albino rats were utilized. A diabetes model was induced using streptozotocin. Relax responses were assessed by various parameters, including blood glucose levels, weight, HbA1c, insulin levels, immunohistochemical analysis for aorta and pancreatic tissues, and relevant genes.
resultsIn this study, safranal treatment in three different doses did not affect weight but significantly reduced blood glucose levels depending on the dosage and duration of administration. HbA1c levels decreased, while insulin levels increased in treated rats. Insulin antibody staining in pancreatic tissues increased. Safranal treatment also reduced VCAM-1 gene expression and increased eNOS gene expression in thoracic aortic tissues. Additionally, safranal improved acetylcholine relaxation responses in isolated organ bath examinations.
conclusionSafranal demonstrates antidiabetic properties in streptozotocin-induced diabetic rats and has the potential to protect against diabetes-induced endothelial dysfunction.
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