ArticleCurrent microbiology2025
Presence of Human-Associated Clade Marker Gene HAC-G19 in Streptococcus suis Isolated From Humans and Swine.
Article in Current microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Streptococcus suis is a zoonotic pathogen contributing to human and pig infections. Effective techniques to distinguish pathogenic from non-pathogenic pathotypes of S. suis is required for public health surveillance. Herein, we developed and evaluated a PCR approach detecting the human-associated clade (HAC)-G19 marker gene to identify the pathogenic pathotype of S. suis. The study was conducted on 599 human strains, 82 diseased-pig strains, and 299 clinically healthy pig strains. PCR analysis revealed that 98.8% and 75.6% were HAC-G19 positive in human and diseased-pig strains, whereas 67.6% of healthy pig strains were negative for the HAC-G19 gene. Statistical analysis revealed that the HAC-G19 gene was more significantly present in diseased-associated isolates than in healthy pig isolates (p-value < 0.001), being with OR of 50.4 (95% CI = 32.1-79.5). Diagnostic accuracy was 87.4% (95% CI = 85.1-89.49%) with sensitivity and specificity were 96.1% (95% CI = 94.3-97.4%) and 67.6% (95% CI = 61.9-72.8%), respectively. This demonstrated that PCR of HAC-G19 has a potential to predict pathogenic pathotype for S. suis.
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