Evidence map›Paper›PMID 40690013›Full record

ReviewNaunyn-Schmiedeberg's archives of pharmacology2025

Unlocking the role of tRNA-derived fragments in shaping breast cancer signaling.

Chou-Yi Hsu, Saade Abdalkareem Jasim, Renuka S Jyothi, Irfan Ahmad, Ahmed Hjazi, Mahmood Hasen Shuhata Alubiady, Aashna Sinha, Yasser Fakri Mustafa, Ahmed Muzahem Al-Ani, Ahmed Hussn

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In one paragraph

Review in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chou-Yi HsuThunderbird School of Global Management, Arizona State University, Tempe Campus, Phoenix, AZ, 85004, USA. chouyihs@asu.edu.
Saade Abdalkareem JasimMedical Laboratory Techniques Department, College of Health and Medical Technology, University of Al-maarif, Anbar, Iraq. saade.a.j@uoa.edu.iq.
Renuka S JyothiDepartment of Biotechnology and Genetics, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, India.
Irfan AhmadDepartment of Clinical Laboratory Sciences, College of Applied Medical Science, King Khalid University, Abha, Saudi Arabia.
Ahmed HjaziDepartment of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia.
Mahmood Hasen Shuhata AlubiadyDepartment of Medical Engineering, Al-Hadi University College, Baghdad, 10011, Iraq.
Aashna SinhaSchool of Applied and Life Sciences, Division of Research and Innovation, Uttaranchal University, Dehradun, Uttarakhand, India.
Yasser Fakri MustafaDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, 41001, Iraq.
Ahmed Muzahem Al-AniDepartment of Medical Engineering, Al-Nisour University College, Baghdad, Iraq.
Ahmed HussnDepartment of Medical Analysis, Medical Laboratory Technique College, The Islamic University, Najaf, Iraq.

Funding

King Khalid University R.G.P.1/323/44
6 · The paper itself

Abstract

A new class of tiny non-coding RNAs (ncRNAs) known as tRNA-derived fragments (tRFs) is produced when mature tRNAs or tRNA precursors are cleaved. The discovery of more and more tRFs with essential roles in many physiological and pathological processes has been made possible by advancements in high-throughput sequencing. tRFs are considered important regulators of human disorders, particularly cancer, because they may control cell viability, differentiation, and homeostasis via various methods. Furthermore, there is growing evidence that extracellular tRFs could be used as potential biomarkers for cancer liquid biopsy diagnosis and prognosis. The biogenesis, categorization, and alteration of tRFs are the main topics of this review. We also provide an overview of the various roles that tRFs play in breast cancer (BC), focusing on the state of studies and future directions for tRFs in this field.

Indexed as

Breast NeoplasmsRNA, TransferAnimalsBiomarkers, TumorFemaleHumansSignal TransductionBiomarkers, TumorRNA, TransferApoptosisBreast cancerCancer cell signalingCell viabilityTRFsTRNA-derived fragments

Identifiers

PMID40690013

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.