Evidence map›Paper›PMID 40690005›Full record

ReviewJournal of neurology2025

The heart-brain axis: neurocognitive frailty in heart failure.

Olayiwola Bolaji, Yasemin Bahar, Sameer Lohana, Abdul Rasheed Bahar, Ibiyo Lawrence, Sula Mazimba

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Olayiwola BolajiCardiology Division, Department of Internal Medicine, Memorial Sloan Kettering Cancer Center, New York, NYC, USA.
Yasemin BaharDepartment of Internal Medicine, Wayne State University/Detroit Medical Center, E Canfield St, Detroit, MI, 48201, USA. ybahar@wayne.edu.ORCID http://orcid.org/0000-0003-4786-8088
Sameer LohanaDepartment of Internal Medicine, Nuvance Health Vassar Brothers Medical Center, Poughkeepsie, NY, 12601, USA.
Abdul Rasheed BaharDepartment of Internal Medicine, Wayne State University/Detroit Medical Center, E Canfield St, Detroit, MI, 48201, USA.
Ibiyo LawrenceDivision of Diversity, Equity and Inclusion Department, RWJMS, Brunswick, New Jersey, USA.
Sula MazimbaAdvent Health Medical Group Transplant Institute, Orlando, FL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heart failure (HF) and neurocognitive frailty (NCF) represent an increasingly recognized clinical intersection with profound implications for patient outcomes. Recent epidemiological data reveal that 40-60% of HF patients experience cognitive impairment, with prevalence increasing proportionally with disease severity. This cognitive-functional decline manifests as structural brain abnormalities, deficits in multiple cognitive domains, and reduced physical capabilities, collectively compromising self-care, increasing healthcare utilization, and elevating mortality risk by up to twofold. This comprehensive review examines the complex bidirectional relationship between HF and NCF, synthesizing current evidence on pathophysiological mechanisms, clinical assessment approaches, and management strategies. The pathophysiology involves interrelated processes, including cerebral hypoperfusion, blood-brain barrier disruption, neuroinflammation, oxidative stress, and neurohumoral dysregulation-all contributing to accelerated brain aging and functional decline. Clinical assessment requires a multidimensional approach utilizing validated cognitive and frailty tools, biomarkers, neuroimaging, and functional measures. Management necessitates integrated strategies spanning optimized pharmacotherapy, device-based interventions, cognitive rehabilitation, structured exercise, nutritional support, and coordinated multidisciplinary care. Emerging evidence suggests that early intervention may attenuate cognitive decline and improve outcomes. As the prevalence of both conditions continues to rise, future research directions should focus on standardized assessment protocols, novel therapeutic targets, and innovative care delivery models to address this challenging clinical syndrome and improve quality of life for this vulnerable population.

Indexed as

BrainCognitive DysfunctionFrailtyHeart FailureHumansCerebral hypoperfusionCognitive frailtyCognitive impairmentHeart failureMultidisciplinary careNeurocognitive frailty

Identifiers

PMID40690005

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.