Evidence map›Paper›PMID 40689771›Full record

ArticleEpilepsia2025

The impact of revised definitions on the epidemiology of status epilepticus: A population-based study.

Meike Menche, Clara Jünemann, Jens-Peter Reese, Martin Jünemann, Michael Teepker, Christoph Best, Christian Roth, Ingrid Sünkeler, Elisabeth Pryss, Felix Rosenow and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Status epilepticus: the score question.Frontiers in neurology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Meike MencheEpilepsy Center Hesse, Department for Neurology, University Hospital Marburg, Philipps University, Marburg, Germany.ORCID https://orcid.org/0009-0009-9358-9312
Clara JünemannEpilepsy Center Hesse, Department for Neurology, University Hospital Marburg, Philipps University, Marburg, Germany.ORCID https://orcid.org/0009-0005-9732-3205
Jens-Peter ReeseFaculty of Health Sciences, TH Mittelhessen University of Applied Sciences, Giessen, Germany.
Martin JünemannDepartment for Neurology, University Hospital Giessen, Justus-Liebig-University, Gießen, Germany.ORCID https://orcid.org/0000-0002-8905-3138
Michael TeepkerEpilepsy Center Hesse, Department for Neurology, University Hospital Marburg, Philipps University, Marburg, Germany.
Christoph BestEpilepsy Center Hesse, Department for Neurology, University Hospital Marburg, Philipps University, Marburg, Germany.
Christian RothEpilepsy Center Hesse, Department for Neurology, University Hospital Marburg, Philipps University, Marburg, Germany.
Ingrid SünkelerBDH Clinic for Neurology, Braunfels, Germany.
Elisabeth PryssDepartment of Internal Medicine, Kreiskrankenhaus Frankenberg, Frankenberg, Germany.
Felix RosenowEpilepsy Center Frankfurt Rhine-Main, Center of Neurology and Neurosurgery, University Medical Center Frankfurt, Goethe-University Frankfurt, Frankfurt am Main, Germany.ORCID https://orcid.org/0000-0002-3989-7471
Adam StrzelczykEpilepsy Center Hesse, Department for Neurology, University Hospital Marburg, Philipps University, Marburg, Germany.ORCID https://orcid.org/0000-0001-6288-9915
Leona MöllerEpilepsy Center Hesse, Department for Neurology, University Hospital Marburg, Philipps University, Marburg, Germany.ORCID https://orcid.org/0000-0002-6562-1196
Lena HabermehlEpilepsy Center Hesse, Department for Neurology, University Hospital Marburg, Philipps University, Marburg, Germany.ORCID https://orcid.org/0000-0003-0290-7784
Panagiota-Eleni TsalouchidouEpilepsy Center Hesse, Department for Neurology, University Hospital Marburg, Philipps University, Marburg, Germany.ORCID https://orcid.org/0000-0003-2344-6323
Ole SimonEpilepsy Center Hesse, Department for Neurology, University Hospital Marburg, Philipps University, Marburg, Germany.
Andre KemmlingDepartment of Neuroradiology, University Hospital Marburg, Philipps University, Marburg, Germany.
Christopher NimskyDepartment of Neurosurgery, University Hospital Marburg, Philipps University, Marburg, Germany.
Lars TimmermannEpilepsy Center Hesse, Department for Neurology, University Hospital Marburg, Philipps University, Marburg, Germany.
Katja MenzlerEpilepsy Center Hesse, Department for Neurology, University Hospital Marburg, Philipps University, Marburg, Germany.
Susanne KnakeEpilepsy Center Hesse, Department for Neurology, University Hospital Marburg, Philipps University, Marburg, Germany.ORCID https://orcid.org/0000-0002-6298-0513

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveStatus epilepticus (SE) represents one of the most common neurological emergencies. The International League Against Epilepsy (ILAE) redefined SE duration thresholds from 30 to 5 min for convulsive SE in 2015. We conducted a prospective population-based study to determine SE incidence and outcomes under the revised criteria and compared findings with historical data using the 30-min definition.

methodsA prospective, population-based cohort study was conducted over a period of 18 months to determine the incidence of SE in Germany, replicating the methodology of a first study conducted in this region in 1999. The study included all adults residing within the 35-postcode area, with participation from all regional hospitals and emergency departments. SE cases were prospectively identified and reported. To ensure comparability with the historical data, the analysis focused on the Primary Service Area (PS-Area)-the direct catchment region of the University Hospital Marburg.

resultsA total of 180 adults with SE (96 men, mean age 66.47 years, SD ± 18.5 years, range: 20-94 years). The crude annual incidence in the PS-Area increased from 15.8/100 000 (95% confidence interval [CI] 11.2-21.6) in 1999 to 29.4/100 000 adults (95% CI 20.5-40.0). It was higher in men than in women (30.9 vs 28.1/100 000, p = .11) and in patients ≥60 years (68.5 vs 13.5/100 000; p < .0001). The calculated age- and gender-adjusted incidence was 32.5/100 000 in the PS-Area. The case-fatality rate was 5.77% (95% CI 1.2%-12.7%) and the crude annual cause-specific mortality rate per 100 000 is 1.70 (95% CI 0.21-4.73). In 53% SE was the first seizure episode; only 47% had a history of epilepsy. When extrapolating these findings to the entire German population, there were at least 20 000 cases of SE with 1000 associated deaths annually. SIGNIFICANCE: These findings provide new epidemiologic evidence that the incidence of SE has increased by ~12% with the adoption of the ILAE 2015 definition, underscoring the impact of updated diagnostic criteria on epidemiological estimates.

Indexed as

Status EpilepticusAdultAgedAged, 80 and overCohort StudiesFemaleGermanyHumansIncidenceMaleMiddle AgedProspective StudiesYoung Adultcase–fatality rateepidemiologyepilepsyetiologyincidencemortalitystatus epilepticus

Identifiers

PMID40689771
PMCPMC12661285

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.