Evidence map›Paper›PMID 40689673›Full record

Trial reportAnaesthesia2025

Comparison of two peripheral regional analgesic techniques for primary elective total hip arthroplasty: a randomised clinical trial.

Francesca Buffoli, Claudia Bonetti, Camilla Pugno, Andrea Minini, Silvia Bettinelli, Arianna Mancini, Alessandro Colombi, Alberto Benigni, Edward R Mariano, Luca F Lorini and 1 more

Abstract readRandomized Controlled TrialComparative Study
In one paragraph

Trial report in Anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pericapsular nerve group block for total hip arthroplasty: A systematic review.The Journal of international medical research · 2026
    Pooled it
  2. Trial
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Francesca BuffoliDepartment of Anesthesia and ICU, Mellino Mellini Hospital, Chiari, Italy.
Claudia BonettiEmergency and Intensive Care Department, ASST Papa Giovanni XXIII, Bergamo, Italy.
Camilla PugnoEmergency and Intensive Care Department, ASST Papa Giovanni XXIII, Bergamo, Italy.
Andrea MininiEmergency and Intensive Care Department, ASST Papa Giovanni XXIII, Bergamo, Italy.
Silvia BettinelliEmergency and Intensive Care Department, ASST Papa Giovanni XXIII, Bergamo, Italy.
Arianna ManciniEmergency and Intensive Care Department, ASST Papa Giovanni XXIII, Bergamo, Italy.
Alessandro ColombiDepartment of Orthopedics and Traumatology, ASST Papa Giovanni XXIII, Bergamo, Italy.
Alberto BenigniEmergency and Intensive Care Department, ASST Papa Giovanni XXIII, Bergamo, Italy.
Edward R MarianoDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Luca F LoriniEmergency and Intensive Care Department, ASST Papa Giovanni XXIII, Bergamo, Italy.
Dario BugadaEmergency and Intensive Care Department, ASST Papa Giovanni XXIII, Bergamo, Italy.ORCID 0000-0002-8363-6674

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSeveral regional anaesthesia techniques have been used in the peri-operative pain management of patients who undergo primary elective total hip arthroplasty. The erector spinae plane, pericapsular nerve group and lateral femoral cutaneous nerve blocks offer motor-sparing analgesia of the hip region but target different areas. We designed this study to compare the pericapsular nerve group block combined with lateral femoral cutaneous nerve block with the erector spinae plane block in terms of postoperative analgesia and motor impairment.

methodsOur study involved patients undergoing primary elective unilateral total hip arthroplasty. All patients received spinal anaesthesia and standardised peri-operative multimodal analgesia. Patients were assigned at random to either pericapsular nerve group and lateral femoral cutaneous nerve blocks ('anterior' block group) or erector spinae plane block ('posterior' block group). The primary outcome was intravenous morphine consumption within the first 24 h postoperatively. Secondary outcomes included: pain scores; assessment of sensory and motor block; incidence of complications; and incidence of chronic postsurgical pain.

resultsSixty-two patients completed the study. The study groups were comparable in baseline characteristics. There was no difference in morphine consumption at 24 h between patients allocated to the anterior and posterior block groups (median (IQR [range]) 5 (1-10 [0-22]) mg vs. 5 (2-8.5 [0-20]) mg, respectively; p > 0.99). Incidence of motor block was 1/31 for patients allocated to the anterior block group compared with 5/31 for those allocated to the posterior block group (p = 0.09). There were no differences in any of the secondary outcome measures between groups. DISCUSSION: We found no statistically or clinically relevant difference between two motor-sparing peripheral regional analgesic techniques among patients undergoing primary elective total hip arthroplasty with multimodal analgesia. Appropriate choice of block may be situation-dependent, and physicians should consider patient and system factors when selecting a technique.

Indexed as

Anesthesia, ConductionArthroplasty, Replacement, HipNerve BlockPostoperative PainAgedAnalgesics, OpioidAnesthesia, SpinalElective Surgical ProceduresFemaleFemoral NerveHumansMaleMiddle AgedMorphinePain MeasurementAnalgesics, OpioidMorphineerector spinae plane blockhip arthroplastyPENG blockpericapsular nerve grouppostoperative pain

Identifiers

PMID40689673
PMCPMC12614412

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.