Evidence map›Paper›PMID 40689646›Full record

ArticleJournal of bacteriology2025

DNA replication initiation timing is important for maintaining genome integrity.

Tristan T Reed, Abigail H Kendal, Katherine J Wozniak, Lyle A Simmons

Abstract read
In one paragraph

Article in Journal of bacteriology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. DnaE uses strand displacement synthesis during Okazaki fragment repair.bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Tristan T ReedDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0009-0007-7479-9635
Abigail H KendalDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0009-0005-9909-9374
Katherine J WozniakDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-3406-3689
Lyle A SimmonsDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-9600-7623

Funding

Cellular Biotechnology Training Program (CBTP)T32GM008353 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHWENDEMAN, ANNA · 1991 to 2021
$9.3M
Novel mechanisms of DNA repair and cell cycle regulation in bacteriaR35GM131772 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lyle Simmons · 2019 to 2026
$2.8M
NIGMS NIH HHS R35 GM131772NIGMS NIH HHS T32 GM008353NIH Cellular Biotechnology Training Program GM008353NIH HHS R35GM131772
6 · The paper itself

Abstract

DNA replication is regulated by factors that promote or inhibit initiation. In

Indexed as

Bacillus subtilisDNA ReplicationGenome, BacterialGenomic InstabilityBacterial ProteinsDNA, BacterialDNA DamageGene Expression Regulation, BacterialMitomycinBacterial ProteinsDNA, BacterialMitomycinBacillus subtilisCcrZDnaADNA replicationRecA

Identifiers

PMID40689646
PMCPMC12369353

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.