ArticleOrganic letters2025
Stereospecific Insertion of Cyclic Amidines into Aryl-Substituted Cyclopropanones: Access to Complex Spirocyclic Aminals.
Article in Organic letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Ring-Enlargement of in Situ Generated Cyclopropanones with Carbonyls and Imines: Synthesis of γ-Butyrolactones and -lactams.Organic letters · 2026Article
- Ring Enlargements of in Situ-Formed Cyclopropanones by Sulfoxonium Ylides: One-Pot Synthesis of Alkylidene Cyclobutanones.The Journal of organic chemistry · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A facile, catalyst-free protocol to access structurally complex spirocyclic aminals from cyclopropanone surrogates and amidines is reported. The two-component reaction is described as a stereospecific insertion of the amidine C═N bond into the C1-C2 bond of the cyclopropanone via the addition of N to the carbonyl group, followed by ring enlargement. The products display similarities to numerous biologically active oligocyclic systems. Further structural diversification is demonstrated, and a proposed mechanism based on experimental and computational evidence is provided.
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Registered trials
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