Evidence map›Paper›PMID 40689397›Full record

ArticleMediators of inflammation2025

HMGB1 Exacerbates Intestinal Barrier Damage by Inducing Ferroptosis Through the TLR4/NF-κB/GPX4 Pathway in Ulcerative Colitis.

Nannan Zhu, Xiaoyuan Ge, Lixue Zhang, Xinwen Chen, Weizhen Xiang, Qiao Mei

Abstract read
In one paragraph

Article in Mediators of inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Identification of Ferro-Aging-Related Biomarkers for Ulcerative Colitis Through Integrated Machine Learning, Single-Cell Analysis, and Spatial Transcriptomics.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Ononin combined withBiochemistry and biophysics reports · 2026
    Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nannan ZhuDepartment of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei City, Anhui Province, China.ORCID https://orcid.org/0009-0009-5718-7877
Xiaoyuan GeDepartment of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei City, Anhui Province, China.ORCID https://orcid.org/0009-0006-6964-2564
Lixue ZhangDepartment of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei City, Anhui Province, China.ORCID https://orcid.org/0009-0004-4444-2414
Xinwen ChenDepartment of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei City, Anhui Province, China.ORCID https://orcid.org/0009-0000-5112-6883
Weizhen XiangDepartment of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei City, Anhui Province, China.ORCID https://orcid.org/0000-0003-3319-2937
Qiao MeiDepartment of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei City, Anhui Province, China.ORCID https://orcid.org/0009-0004-8826-7662

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Colitis, UlcerativeFerroptosisHMGB1 ProteinNF-kappa BToll-Like Receptor 4AnimalsBlotting, WesternCaco-2 CellsDextran SulfateFemaleHumansIntestinal MucosaMaleMiceMice, Inbred C57BLSignal TransductionDextran SulfateHMGB1 ProteinHMGB1 protein, humanNF-kappa BTLR4 protein, humanToll-Like Receptor 4ferroptosisHMGB1intestinal barrierTLR4/NF-κB/GPX4 pathwayulcerative colitis

Identifiers

PMID40689397
PMCPMC12274088

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.