ArticleFrontiers in cellular and infection microbiology2025
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Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Immunosuppression in poultry production, particularly in high-value species like the Chinese yellow quail (Coturnix japonica), increases disease susceptibility and economic losses. Plant-derived polysaccharides, such as those from Methods: One hundred and twenty 21-day-old healthy quails were randomly divided into six groups (n=20/group): a blank control (saline), a model group (saline + CTX), and four RTCP-treated groups (0.25, 0.5, 0.75, 1 g/kg + CTX). CTX (80 mg/kg) was administered intramuscularly (days 4-7) to induce immunosuppression, except in the blank control. Spleen indices, histology, cytokine profiles, antibody titers, GATA-3/T-bet mRNA expression, and transcriptional networks were analyzed. Results: CTX significantly reduced spleen weight, organ indices, cytokine levels, and antibody titers (P<0.05). Compared to the model group, 0.5 g/kg RTCP restored spleen morphology and function, elevated cytokines (e.g., IL-2, IFN-γ) and immunoglobulins, and upregulated complement components (C3, C5) and acute-phase proteins, enhancing T-cell and B-cell activation (P<0.05). RTCP also rebalanced the Th1/Th2 axis by normalizing the T-bet/GATA-3 ratio, indicating immune homeostasis recovery. Discussion: RTCP effectively counteracted CTX-induced immunosuppression by modulating innate and adaptive immunity, including complement activation and Th1/Th2 balance. These findings highlight RTCP's potential as a natural immunomodulator in poultry. Further research should optimize dosing and explore gut-microbiota-immune interactions to enhance therapeutic applications.
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