ArticleFrontiers in neurology2025
Serum cytokine profiles in patients with myasthenia gravis.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Cytokine Profiles in Myasthenia Gravis Subgroups and the Lack of Any Effect of Immunosuppression.Muscle & nerve · 2026Article
- The role and mechanism of IL‑35 in myasthenia gravis (Review).International journal of molecular medicine · 2026Review
- Reference intervals for plasma IFN-α, TNF-α, IL-12p70, and IFN-γ by flow cytometry in healthy adults from eastern China: a single-center study.Frontiers in immunology · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Cytokines play a crucial role in instigating inflammation and generating pathogenic autoantibodies at the neuromuscular junction in individuals suffering from myasthenia gravis (MG). The objective of this study is to investigate the cytokine profiles among patients grappling with MG. Methods: This study recruited patients with unstable MG and healthy controls from the First Affiliated Hospital of Fujian Medical University during the period spanning January 2021 to December 2022. We evaluated IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12P70, IL-17, IFN-γ, IFN-α, and TNF-α in the serum using the Flow Cytometric Bead Array (CBA) technique. Results: A total of 104 patients and 54 healthy controls were included in the study. Notably, serum levels of interleukin (IL)-1β, IL-2, IL-10, and IL-17 exhibited significant elevation in unstable MG patients when compared to the healthy control group. Furthermore, levels of IL-1β and IL-5 were notably higher in unstable MG patients who tested negative for acetylcholine receptor (AChR) antibodies when compared to their AChR-antibody positive counterparts ( Conclusion: Individuals with unstable MG appear to demonstrate elevated levels of serum IL-1β, IL-2, IL-10, and IL-17 compared to healthy individuals. Furthermore, among MG subgroups, those testing negative for antibodies, tend to display increased levels of IL-1β and IL-5. These serum cytokine profiles may hold promise as potential biomarkers for stratifying MG patients in clinical settings.
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