Evidence map›Paper›PMID 40689257›Full record

ArticleOphthalmology science

Dark Adaptometry Kinetics Differentiates Age-Related Macular Degeneration from Central Serous Chorioretinopathy.

Ashwin P Verghese, Claudia C Lasalle, David J Ramsey

Abstract read
In one paragraph

Article in Ophthalmology science. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Rapid Macular Thinning as a Biomarker for Geographical Atrophy.Clinical ophthalmology (Auckland, N.Z.) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ashwin P VergheseDivision of Ophthalmology, Department of Surgery, UMass Chan - Lahey School of Medicine, Burlington, Massachusetts.
Claudia C LasalleDivision of Ophthalmology, Department of Surgery, UMass Chan - Lahey School of Medicine, Burlington, Massachusetts.
David J RamseyDivision of Ophthalmology, Department of Surgery, UMass Chan - Lahey School of Medicine, Burlington, Massachusetts.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To assess the diagnostic utility of dark adaptometry (DA) rod intercept time (RIT) to differentiate age-related macular degeneration (AMD) from central serous chorioretinopathy (CSCR). Design: Retrospective consecutive case series. Participants: Consecutive patients with a clinical diagnosis of AMD or CSCR who were ≥50 years of age. Methods: The study included patients who had completed a DA study in ≥1 eye measured at 5° superior to the fovea on the retina. All patients underwent a comprehensive retina examination, including OCT assessment of the macula. Main Outcome Measures: Patients were classified based on their RIT, with an RIT >6.50 minutes considered a delay. Results: The study included 67 patients with AMD and 25 with CSCR. Patients with AMD tended to be older (73.8 ± 8.9 years vs. 65.0 ± 7.2 years, Conclusions: Prolonged dark adaptation, indicated by a longer RIT, is capable of distinguishing individuals with AMD from CSCR, 2 conditions that share similar fundus features. Future investigations are warranted to assess the effectiveness of this noninvasive technique for AMD screening. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Indexed as

Age-related macular degenerationCentral serous chorioretinopathyDark adaptationDark adaptometryRod intercept time

Identifiers

PMID40689257
PMCPMC12271418

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.