ArticleOpen forum infectious diseases2025
Incidence of Human Metapneumovirus Among Older Adults in 10 High-Income Countries: A Systematic Literature Review, Meta-analysis, and Modeling Study.
Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Optimization of the antiviral spectrum of cyclophilin inhibitors targeting respiratory viruses.Antimicrobial agents and chemotherapy · 2026Article
- Spatiotemporal Dynamics of Human Metapneumovirus and Potential Impact of Respiratory Syncytial Virus Interventions in the United States.medRxiv : the preprint server for health sciences · 2026Article
- Acute Respiratory Failure and Ventilatory Support in Hospitalized Adults With Viral Respiratory Infection: A Retrospective Cohort Study.Open forum infectious diseases · 2026Article
- Comparison of Hospitalization Costs Associated With Human Metapneumovirus and Respiratory Syncytial Virus Infection in US Adults.Open forum infectious diseases · 2026Article
- Epidemiological Burden and Hospitalization Trends of Human Metapneumovirus in Spain (2016-2023): A Retrospective Study.Infectious diseases and therapy · 2026Article
- Epidemiology and Burden of Human Metapneumovirus Among Italian Adults in Outpatient and Inpatient Settings, 2014-2025.Influenza and other respiratory viruses · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The epidemiologic landscape for human metapneumovirus (hMPV), a respiratory pathogen, is poorly characterized, particularly among older adults. Methods: Leveraging the latest estimates of lower respiratory infection (LRI) incidence from the Global Burden of Disease Study 2021 and meta-analyzed findings from a systematic literature review, we quantified the incidence of LRI with hMPV in 10 high-income locations among older adults in the most recent prepandemic year (2019): Canada, Chile, France, Germany, New Zealand, Netherlands, Italy, Spain, United Kingdom, and United States. Results: The systematic literature review identified 21 studies with data on the percentage of LRI episodes associated with hMPV in adults aged ≥60 years in the targeted locations. Combining the meta-analyzed percentage of LRI cases associated with hMPV from these studies (7.0%; 95% CI, 5.4%-9.1%) with age-, sex-, and location-specific estimates of LRI incidence from the Global Burden of Disease Study 2021, we estimated that hMPV incidence rates per 100 000 in 2019 among adults aged ≥60 ranged from 185.7 (95% uncertainty interval, 134.7-251.1) in Italy to 462.1 (333.1-628.2) in the United States. Conclusions: Overall, our literature review, meta-analysis, and modeling study confirm a significant burden of hMPV-associated LRI in older adults. This work fills a critical evidence gap in the epidemiologic landscape of hMPV and yields actionable estimates to inform vaccine development strategies and other strategic initiatives. Future inclusion of hMPV in routine surveillance would enable more comprehensive estimates of hMPV incidence and outcomes.
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