ArticleOpen forum infectious diseases2025
Infection Risk Associated With Colonization by Multidrug-Resistant Gram-Negative Bacteria: An Umbrella Review and Meta-analysis.
Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gut Microbiota Alterations Associated With Colonization by Multidrug-Resistant Organisms in ICU Patients: First Systematic Review and Meta-Analysis.MicrobiologyOpen · 2026Pooled it
- A posttranslational modification of fimbriae drives pathogenicity inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Beyond Colonization: Dynamic Risk Stratification and Clinical Decision-Making for MDR Gram-Negative Infections in Critically Ill Patients.Biomedicines · 2026Review
- ICU Admission Screening for Multidrug-Resistant Organism Colonization and Subsequent Infection Risk: A Pilot Study.Diagnostics (Basel, Switzerland) · 2026Article
- Impact of colonisation with multidrug-resistant gram-negative bacteria in a low endemicity setting: a population-based observational study.Infection · 2026Article
- Current infection control practices for multidrug-resistant organisms (MDRO): a survey of the Society for Healthcare Epidemiology of America (SHEA) research network and affiliated US-based hospitals.Infection control and hospital epidemiology · 2026Article
- Association between MDROs colonization and subsequent infections in ICU patients: a retrospective cohort study.Frontiers in public health · 2026Article
- Risk Factors Associated with Community-Onset Infections Due to Multidrug-Resistant Organisms.Antibiotics (Basel, Switzerland) · 2025Article
- Therapeutic management of health care-associated pneumonia.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2025Review
- The gut microbiome as a major source of drug-resistant infections: emerging strategies to decolonize and target the gut reservoir.Frontiers in cellular and infection microbiology · 2025Review
- Multidrug-Resistant Gram-Negative Urinary Tract Infections (UTIs) Increase the Risk of Rejection, CMV Viremia, and Graft Loss After Kidney Transplantation.Transplant infectious disease : an official journal of the Transplantation SocietyArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Infections following colonization of multidrug-resistant gram-negative bacteria (MDR-GNB), particularly Enterobacterales with extended-spectrum beta-lactamases (ESBL-E) or carbapenem-resistant Enterobacterales (CRE), represent a major global health threat. Our aim was to assess quality of evidence and provide estimates on rate of infection following colonization with multidrug-resistant gram-negative bacteria. Methods: We performed an umbrella review of systematic reviews and meta-analyses. Quality was assessed using the AMSTAR 2 tool, and a meta-analysis was performed to estimate rate of infection. Results: An initial search for systematic reviews and meta-analyses yielded 847 results, with 17 articles ultimately included. After exclusion of 2 studies for overlapping results and very low quality, the pooled incidence of infection following colonization across the studies was 22% for ESBL-E and 22% for CRE. Few reviews included high-quality findings on mortality or transmission following colonization. Additionally, only a limited number of reviews included findings related to MDR Conclusions: Our results suggest a substantial rate of infection following colonization of multidrug-resistant gram-negative bacteria. These findings can inform individual patient counseling, future decolonization innovation, clinical trial design, and regulatory approval of new decolonization agents. However, the heterogeneity of the included populations may limit the generalizability of these findings.
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