ArticleFrontiers in pediatrics2025
Effect of chorioamnionitis on necrotizing enterocolitis in preterm infants: a multicenter cohort study.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 citing papers in PubMed.
- Antimicrobial-associated adverse events in neonates: an integrated literature review and FAERS pharmacovigilance analysis.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Serum Neutrophil Gelatinase-Associated Lipocalin, Total Oxidant Status, and Total Antioxidant Status in Preterm Infants Following Clinical Chorioamnionitis or Preterm Premature Rupture of Membranes: A Multicenter Prospective Cohort Study.Children (Basel, Switzerland) · 2026Article
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18 authors.
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Abstract
Background: To explore the association between maternal chorioamnionitis (CAM) exposure and necrotising enterocolitis (NEC) in very preterm infants (VPI) or very low birth weight (VLBWI). Methods: The aim of this multicentre cohort study was to investigate the impact of maternal CAM and its different staging on VPI or VLBWI NEC in six medical centres in Shenzhen between 2022 and 2023. The primary outcome was NEC (Bell staging ≥ II) and secondary outcomes included NEC or in-hospital mortality. Logistic regression adjusted for confounders identified through directed acyclic graphs (DAG) and literature review. The interaction effect of premature rupture of membranes was assessed using stratification and likelihood ratio tests. Results: In the cohort study, the prevalence of CAM was 44.31%, the prevalence of NEC was 5.38%, and the prevalence of NEC or death was 7.69%. Of the 288 participants whose mothers had been exposed to CAM, 1.04% had clinical CAM, 96.53% had histological CAM, and 2.43% were diagnosed with confirmed CAM. CAM was associated with NEC or death (aOR = 1.90, 95% CI 1.02-3.55); the confirmed CAM group showed a stronger association (aOR = 7.14, 95% CI 1.20-42.35). In preterm infants, CAM was significantly associated with NEC or death in cases of preterm membrane rupture (aOR = 2.18, 95% CI 1.07-4.44). Conclusions: There was a significant positive association between CAM and NEC or death in VLBWs or VPIs, which was mainly from the population with confirmed CAM. In premature rupture of membranes, the association between CAM and NEC or death was more significant.
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