ReviewFrontiers in pharmacology2025
Review projecting shikonin as a therapeutic candidate in female carcinomas: a preclinical perspective.
Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bioactive substances, especially shikonin (naphthoquinone), which is extracted from Lithospermum erythrorhizon, have drawn much attention as promising substitutes for preventing cancer malignancy. Shikonin (SK) has displayed a broad spectrum of anticancer activities, such as necroptosis, cell cycle invasion, Autophagy, apoptosis, Diabetes, DNA damage induction, and suppression of angiogenesis. It reverses drug resistance and inhibited cancer cell growth by altering their metabolism. According to preliminary clinical trials, shikonin may improve the effectiveness of known chemotherapeutic drugs, radiation therapies, and immunotherapies through synergistic and additive interactions in female carcinomas. Despite its potential, additional investigation is required to pinpoint exact processes by which shikonin causes metabolic reprogramming in female cancers. While numerous researches have been reported to understanding the anticancer potential of shikonin, more research is needed to investigate its synergistic effects with conventional cancer therapies and assessing its clinical efficacy in robust trials. Due to less clinical data, more number of clinical trials is vital to establish their efficacy and safety in human patients, while mechanistic experimentation could unveil new therapeutic oncotargets in managing female carcinomas.
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