ArticleVeterinary world2025
Effect of idebenone supplementation in a semen extender on boar spermatozoa quality during liquid storage.
Article in Veterinary world, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Idebenone reduces oxidative stress and differentially improves chromatin integrity in dog and cat epididymal spermatozoa after slow freezing and vitrification.Veterinary research communications · 2026Article
- Effects of Pre- and Post-treatment of Idebenone on the Side Effects of the Chemotherapy Model with Cyclophosphamide in the Rat Ovary.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Perspectives in porcine semen conservation (liquid and frozen).The Journal of reproduction and development · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aim: In swine production, over 99% of artificial insemination (AI) procedures utilize boar semen preserved in liquid form at 17°C for up to 5 days. However, spermatozoa are highly susceptible to oxidative stress during storage, which impairs motility, membrane integrity, and overall fertility. Reactive oxygen species-induced lipid peroxidation (LPO) compromises sperm structure and function. Although antioxidants are used to mitigate oxidative damage, idebenone (IDB) - a short-chain benzoquinone with potent mitochondrial antioxidant properties - has not been studied in boar semen preservation. This study aimed to investigate the effects of IDB supplementation in a semen extender on boar spermatozoa quality during 120 h of liquid storage at 17°C. Materials and Methods: Ejaculates from 25 Duroc boars were diluted with Beltsville Thawing Solution to a final concentration of 30 × 10 Results: After 120 h, the 78 nM IDB group showed significantly improved total motility (81.4%) and membrane integrity (60.3%) compared to control (72.9% and 46.7%, respectively; p < 0.05). Viability was higher in IDB-treated groups, and high concentrations (625-1250 nM) reduced motility. In Experiment 2, 78 nM IDB improved total and progressive motility (84.0% and 46.8%), preserved acrosome integrity (64.06% vs. 58.75%), reduced capacitated sperm (64.72% vs. 59.11%), and decreased malondialdehyde levels (51.84 nmol vs. 59.61 nmol) relative to controls (p < 0.05). Conclusion: IDB at 78 nM effectively preserves boar semen quality during 5-day liquid storage by enhancing motility, viability, membrane and acrosome integrity, and reducing oxidative stress. These findings highlight its potential as a novel antioxidant additive in AI protocols.
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Registered trials
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