Evidence map›Paper›PMID 40689081›Full record

ArticleJournal of magnetic resonance open2025

Hyperpolarized [1-

Karen Dos Santos, Salva R Yurista, Sophia M Mirrione, David O Guarin Bedoya, Samuel R Calos, Ivan Luptak, Atsushi M Takahashi, Wai Hong Wilson Tang, Yoshiko Iwamoto, Christopher T Nguyen and 1 more

Abstract read
In one paragraph

Article in Journal of magnetic resonance open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Karen Dos SantosAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.ORCID 0000-0003-1233-8490
Salva R YuristaAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Sophia M MirrioneAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
David O Guarin BedoyaAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Samuel R CalosAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Ivan LuptakMyocardial Biology Unit, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Atsushi M TakahashiDepartment of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Wai Hong Wilson TangDepartment of Cardiovascular Medicine, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.
Yoshiko IwamotoCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Christopher T NguyenAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Yi-Fen YenAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.ORCID 0000-0001-9986-5327

Funding

TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Daniel B Vigneron · 2011 to 2026
$19.9M
Serial evaluation of cardioprotective effects of exercise training in heart failure using cardiac diffusion tensor MRIR01HL151704 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NGUYEN, CHRISTOPHER T · 2020 to 2024
$3.4M
Microstructural Response of the Myocardium to Mechanical LoadR01HL159010 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MEKKAOUI, CHOUKRI, NGUYEN, CHRISTOPHER T · 2021 to 2024
$3.2M
Modeling, measurement and prediction of cardiac magneto-stimulation thresholdsR01EB033853 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Bastien Guerin, Christopher T Nguyen · 2023 to 2026
$2.4M
Targeting Energetics to Improve Outcomes in Hypertrophic CardiomyopathyR01HL166606 · NHLBI · BOSTON MEDICAL CENTER · PI Ivan Luptak · 2024 to 2026
$2.4M
Carbon-13 Polarizer for Metabolic MR ImagingS10OD021768 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI YEN, YI-FEN · 2017 to 2017
$1.9M
Console Upgrade for 4.7T PET-MRI Preclinical ScannerS10OD034258 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI FARRAR, CHRISTIAN T · 2023 to 2023
$600k
Upgrade to 3 Tesla MRI scanner for brain imaging at MITS10OD021569 · OD · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIELI, JOHN · 2016 to 2016
$600k
Hyperpolarized MR-PET for evaluating mitochondrial function and availability in an Alzheimers Disease ModelR21AG086721 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI WEY, HSIAO-YING, YEN, YI-FEN · 2024 to 2024
$456k
Next generation metabolic imaging of the effect of exercise on mitochondrial function in Alzheimer's diseaseR03AG087483 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI YEN, YI-FEN · 2024 to 2024
$332k
NHLBI NIH HHS R01 HL151704NHLBI NIH HHS R01 HL159010NHLBI NIH HHS R01 HL166606NIA NIH HHS R03 AG087483NIA NIH HHS R21 AG086721NIBIB NIH HHS P41 EB013598NIBIB NIH HHS R01 EB033853NIH HHS S10 OD021569NIH HHS S10 OD021768NIH HHS S10 OD034258
6 · The paper itself

Abstract

We evaluated altered cardiac metabolism in Zucker Spontaneously Hypertensive Fatty (ZSF1) rats fed an isocaloric high-fat diet versus normal chow using hyperpolarized (HP) [1-

Indexed as

Cardiac metabolismHEpEFHyperpolarized 13CMagnetic resonance spectroscopic imagingZSF1 rat model

Identifiers

PMID40689081
PMCPMC12273856

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.