Evidence map›Paper›PMID 40689065›Full record

ReviewAmerican journal of cardiovascular disease2025

An updated meta-analysis on the association between celiac disease and cardiovascular diseases.

Mahdi Faraji, Reza Khademi, Maede Maleki, Fatemeh Jafari, Ensiyeh Olama, Mohammad Sadra Saghafi, Anita Fatehi, Elnaz Olama, Danial Abasi Dehkordi, Aydin Hassanpour Adeh and 7 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in American journal of cardiovascular disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Mahdi FarajiStudents Research Committee, School of Medicine, Ardabil University of Medical Sciences Ardabil 56189-85991, Iran.
Reza KhademiStudent Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences Mashhad 91388-13944, Iran.
Maede MalekiStudents Research Committee, School of Medicine, Ardabil University of Medical Sciences Ardabil 56189-85991, Iran.
Fatemeh JafariStudent Research Committee, School of Medicine, Alborz University of Medical Sciences Alborz 31497-79453, Iran.
Ensiyeh OlamaStudent Research Committee, School of Medicine, SEU University of Medical Sciences, Georgian National University SEU Tbilisi 0144, Georgia.
Mohammad Sadra SaghafiStudent Research Committee, Qom University of Medical Sciences Qom 37158-35155, Iran.
Anita FatehiSchool of Medicine, Tehran University of Medical Sciences Tehran 0098, Iran.
Elnaz OlamaFaculty of Medicine, Georgian National University SEU Tbilisi 0166, Georgia.
Danial Abasi DehkordiSchool of Medicine, Isfahan University of Medical Sciences Isfahan 81745-33871, Iran.
Aydin Hassanpour AdehUniversal Scientific Education and Research Network (USERN) Tehran 14197-33151, Iran.
Seyyed Kiarash Sadat RafieiStudents Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences Tehran 19839-69411, Iran.
Komeil Aghazadeh-HabashiStudent Research Committee, Tabriz University of Medical Sciences Tabriz 51656-65811, Iran.
Amin MagsudyIslamic Azad University Tabriz Branch Faculty of Medicine Tabriz 51579-44533, Iran.
Pegah RefahiStudent Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences Mashhad 91379-13199, Iran.
Niloofar DeraviStudents Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences Tehran 19839-69411, Iran.
Zahra KeyhanifarSchool of Medicine, Atilim University Ankara 06830, Turkey.
Mahsa Asadi AnarCollege of Medicine, University of Arizona Tucson, AZ 85724, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesResearch on the relationship between celiac disease (CD) and cardiovascular disease (CVD) is still ongoing, and different studies have reported contradictory findings. To carry out a meta-analysis and systematic review to look into the connection between CD and CVD risk.

methodsA thorough search was conducted in PubMed, Scopus, and Google Scholar databases up to February 19, 2024. Relevant articles were extracted, and the titles, abstracts, and full texts of the related articles were screened. The quality of the studies was assessed using the Joanna Briggs Institute critical appraisal tools.

resultsNine cohort and one case-control studies involving 49,621,333 individuals were included in the meta-analysis. The pooled analysis revealed a 7% increased risk of CVD in CD patients compared to controls (OR: 1.07, 95% CI: 1.03-1.10, P < 0.05). Significant heterogeneity was observed among studies (I

conclusionThis meta-analysis provides evidence of a modest but significant increase in CVD risk in patients with CD. The results highlight the importance of considering cardiovascular health in CD treatment and the need for further research to elucidate the mechanisms underlying this association and to develop targeted prevention strategies.

Indexed as

cardiovascular disease (CVD)Celiac disease (CD)coronary artery disease (CAD)meta-analysissystematic review

Identifiers

PMID40689065
PMCPMC12267083

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.