Evidence map›Paper›PMID 40689057›Full record

ArticleACG case reports journal2025

Tacrolimus-Induced Acute Esophageal Necrosis Postorthotopic Liver Transplantation.

Wei Tang, Makeda Dawkins, Daniel Basta, Nao Hara, Fouzia Shakil, Bodin Roxana, Shireen Pais, Kenji Okumura, Seigo Nishida, Abhay Dhand

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in ACG case reports journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wei TangDivision of General Internal Medicine, Westchester Medical Center, Valhalla, NY.ORCID https://orcid.org/0000-0002-6599-980X
Makeda DawkinsDivision of Gastroenterology and Hepatobiliary Diseases, Westchester Medical Center, Valhalla, NY.
Daniel BastaDivision of General Internal Medicine, Westchester Medical Center, Valhalla, NY.
Nao HaraDepartment of Pathology, Westchester Medical Center, Valhalla, NY.
Fouzia ShakilDepartment of Pathology, Westchester Medical Center, Valhalla, NY.
Bodin RoxanaDivision of Gastroenterology and Hepatobiliary Diseases, Westchester Medical Center, Valhalla, NY.
Shireen PaisDivision of Gastroenterology and Hepatobiliary Diseases, Advanced Endoscopy, Westchester Medical Center, Valhalla, NY.
Kenji OkumuraDivision of Transplant Surgery, Westchester Medical Center, Valhalla, NY.
Seigo NishidaDivision of Transplant Surgery, Westchester Medical Center, Valhalla, NY.
Abhay DhandTransplant Infectious Diseases, Westchester Medical Center, Valhalla, NY.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute esophageal necrosis, or "black esophagus," is a rare but severe condition characterized by circumferential black necrotized esophageal mucosa with an abrupt transition at the gastroesophageal junction. The "two-hit" hypothesis suggests that an initial ischemic insult predisposes the esophageal mucosa to further injury from luminal acid exposure or medications. We present the first documented case of tacrolimus-induced acute esophageal necrosis without preceding hemodynamic instability in a liver transplant recipient, which resolved with discontinuation of tacrolimus and transition to cyclosporin.

Indexed as

acute esophageal necrosisgastrointestinal toxicityimmunosuppressionliver transplanttacrolimus

Identifiers

PMID40689057
PMCPMC12273670

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.