ReviewJAAD international2025
FDA and EMA-approved noninvasive imaging techniques for basal cell carcinoma subtyping: A systematic review.
Review in JAAD international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Photoacoustic imaging-based assessment of vascular changes in scars: a retrospective analysis of factors influencing PDL treatment efficacy.Lasers in medical science · 2026Article
- Exploratory systematic characterization of vascular features in confocal laser endomicroscopy of cutaneous squamous cell carcinoma.Oral and maxillofacial surgery · 2026Article
- Reflectance confocal microscopy detects distinct features of field damage in chronically UV-irradiated SKH1 mouse skin.JID innovations : skin science from molecules to population health · 2026Article
- Line-field confocal optical coherence tomography for diagnosis and treatment monitoring of subtle basal cell carcinomas in a patient with nevoid basal cell carcinoma syndrome.JAAD case reports · 2026Article
- Advances in the Field of Cutaneous Malignancies: Background and Clinical Management.Journal of clinical medicine · 2026Article
- Cost and cost-effectiveness of Mohs micrographic surgery versus conventional excision for nonmelanoma skin cancer: A scoping review.JAAD international · 2026Review
- Surgical Management of Cutaneous Neoplasms: Biopsy Strategies, Margin Assessment, and Special Considerations.Dermatopathology (Basel, Switzerland) · 2026Review
- Retrospective Analysis of the Therapeutic Outcomes of Microneedle Radiofrequency on Melasma by Optical Coherence Tomography: A Observational Pilot Study.Diagnostics (Basel, Switzerland) · 2026Article
- Surgical Outcomes of Nonmelanoma Skin Cancer Managed with Systematic Preoperative Reflectance Confocal Microscopy-Guided Margin Assessment: A Retrospective Cohort Study Comparing Wide Local Excision and Mohs Micrographic Surgery.Diagnostics (Basel, Switzerland) · 2026Article
- Characterization of dermatofibromas and epidermoid cysts using dermoscopy-guided high-frequency ultrasound imaging.Journal of ultrasound · 2026Article
- Intraoperative Margin Control in Eyelid Tumor Surgery: Current Standards, Imaging Advances, and Emerging Techniques.Current oncology (Toronto, Ont.) · 2026Review
- ChatGPT, Gemini, and Claude in clinical and dermoscopic image analysis of basal cell carcinoma and its common mimickers: A comparative performance analysis.JID innovations : skin science from molecules to population health · 2026Article
- Co-Localized Dermoscopy and LC-OCT for AI-Assisted Margin Assessment of Basal Cell Carcinoma: Development of a "BCC-One-Stop-Shop" Workflow.Diagnostics (Basel, Switzerland) · 2026Article
- Dermoscopy-guided high-frequency ultrasound: Principles and applications in dermatology.JID innovations : skin science from molecules to population health · 2026Article
- Efficacy of 4% 5-Fluorouracil Cream in the Treatment of Actinic Keratoses: A Single-Center Experience.Journal of clinical medicine · 2026Article
- Dermoscopy-Guided High-Frequency Ultrasound Imaging of Subcentimeter Cutaneous and Subcutaneous Neurofibromas in Patients with Neurofibromatosis Type 1.Journal of clinical medicine · 2026Article
- Cross-Polarized Macro Photography versus Polarized Dermoscopy in Basal Cell Carcinoma: A Blinded Paired-Image Comparison.Clinical, cosmetic and investigational dermatology · 2026Article
- Multispectral Laser-Scanning Photoacoustic Microscopy With SRS-Generated Wavelengths for Skin Chromophore Characterization.Journal of biophotonics · 2026Article
- Real-time LC-OCT monitoring of scalp hypertrophic actinic keratosis clearance following cryotherapy, laser, and 5-fluorouracil therapy.Frontiers in medicine · 2026Article
- Line-Field Confocal Optical Coherence Tomography of Basal Cell Carcinoma: Systematic Correlation with Histopathology.Diagnostics (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Basal cell carcinoma (BCC), the most common skin cancer, requires accurate subtyping for optimal treatment. While histopathology is the gold standard, noninvasive imaging offers a biopsy-free alternative, though its accuracy remains unclear. Objective: To assess the diagnostic accuracy of Food and Drug Administration- and European Medicines Agency-approved noninvasive imaging techniques for BCC subtyping. Methods: A systematic review included 19 studies (2650 lesions) from EMBASE, Scopus, PubMed, and Cochrane Library (published up to November 30, 2024). Evaluated modalities included dermoscopy, high-frequency ultrasound (HFUS), dermoscopy-guided HFUS (DG-HFUS), optical coherence tomography (OCT), high-definition OCT (HD-OCT), dynamic OCT (D-OCT), line-field confocal OCT (LC-OCT), and reflectance confocal microscopy. Results: Dermoscopy showed moderate accuracy (81.9% sensitivity, 81.8% specificity for superficial BCC [sBCC]). DG-HFUS outperformed HFUS (82.4% sensitivity, 91.3% specificity). LC-OCT had the highest accuracy, achieving 100% sensitivity for infiltrative BCC. D-OCT distinguished subtypes at 150 μm depth; branching vessels at 300 μm increased nBCC risk (relative risk = 1.53, Limitations: Study heterogeneity and inconsistent protocols limit comparability. Conclusion: LC-OCT and HD-OCT offer the highest accuracy, while DG-HFUS outperforms dermoscopy and HFUS, making them strong noninvasive alternatives.
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