Evidence map›Paper›PMID 40689041›Full record

ArticleJournal of agricultural, biological, and environmental statistics2025

Multi-omics Integrative Analysis for Incomplete Data Using Weighted

Wenda Zhang, Zichen Ma, Yen-Yi Ho, Shuyi Yang, Joshua Habiger, Hsin-Hsiung Huang, Yufei Huang

Abstract read
In one paragraph

Article in Journal of agricultural, biological, and environmental statistics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wenda ZhangWalmart Global Tech, Sunnyvale, CA 94086 USA.ORCID 0000-0003-0333-3882
Zichen MaDepartment of Mathematics, Colgate University, Hamilton, NY 13346 USA.ORCID 0000-0001-5748-1675
Yen-Yi HoDepartment of Statistics, University of South Carolina, Columbia, SC 29208 USA.ORCID 0000-0002-3224-3184
Shuyi YangDepartment of Statistics, University of South Carolina, Columbia, SC 29208 USA.ORCID 0009-0004-1604-8874
Joshua HabigerDepartment of Statistics, Oklahoma State University, Stillwater, OK 74078 USA.ORCID 0000-0002-4378-0284
Hsin-Hsiung HuangDepartment of Statistics and Data Science, University of Central Florida, Orlando, FL 32816 USA.ORCID 0000-0001-7150-7229
Yufei HuangDivision of Hematology/Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15232 USA.ORCID 0000-0001-6268-5357

Funding

scDECO: A novel statistical framework to identify differential co-expression gene combinations systematically using single-cell RNA sequencing dataR21CA264353 · NCI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI HO, YEN-YI · 2021 to 2022
$357k
NCI NIH HHS R21 CA264353
6 · The paper itself

Abstract

The advancements in high-throughput technologies provide exciting opportunities to obtain multi-omics data from the same individuals in a biomedical study, and joint analyses of data from multiple sources offer many benefits. However, the occurrence of missing values is an inevitable issue in multi-omics data because measurements such as mRNA gene expression levels often require invasive tissue sampling from patients. Common approaches for addressing missing measurements include analyses based on observations with complete data or multiple imputation methods. In this paper, we propose a novel integrative multi-omics analytical framework based on Supplementary Information: The online version contains supplementary material available at 10.1007/s13253-024-00603-3.

Indexed as

Incomplete DataIntegrative multi-omics analysisMissing valueOmnibus testWeighted p-value adjustment

Identifiers

PMID40689041
PMCPMC12274148

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.