Evidence map›Paper›PMID 40689020›Full record

ArticleThe annals of applied statistics2024

SEMIPARAMETRIC LINEAR REGRESSION WITH AN INTERVAL-CENSORED COVARIATE IN THE ATHEROSCLEROSIS RISK IN COMMUNITIES STUDY.

Richard Sizelove, Donglin Zeng, Dan-Yu Lin

Abstract read
In one paragraph

Article in The annals of applied statistics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Richard SizeloveDepartment of Biostatistics, University of North Carolina at Chapel Hill.
Donglin ZengDepartment of Biostatistics, University of Michigan.
Dan-Yu LinDepartment of Biostatistics, University of North Carolina at Chapel Hill.

Funding

STATISTICAL ISSUES IN AIDS RESEARCHR37AI029168 · NIAID · UNIVERSITY OF WASHINGTON · PI JAMES P HUGHES · 1999 to 2026
$9.8M
Leveraging multi-omics approaches to examine metabolic challenges of obesity in relation to cardiovascular diseasesR01HL143885 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI AVERY, CHRISTY LEIGH, GORDON-LARSEN, PENNY · 2019 to 2022
$8.9M
STATISTICAL ISSUES IN AIDS RESEARCHR01AI029168 · NIAID · UNIVERSITY OF WASHINGTON · PI HUGHES, JAMES P · 1989 to 2018
$5.3M
Statistical and Machine Learning Methods to Improve Dynamic Treatment Regimens Estimation Using Real World Data.R01GM124104 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Yuanjia Wang, Donglin Zeng · 2018 to 2026
$3.1M
Semiparametric Analysis of Big Censored DataR01HL149683 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIN, DANYU · 2020 to 2023
$1.9M
Semiparametric Regression Analysis of Interval-Censored Data in Current Cohort StudiesR01HL173128 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Donglin Zeng · 2024 to 2026
$1.2M
NHLBI NIH HHS R01 HL143885NHLBI NIH HHS R01 HL149683NHLBI NIH HHS R01 HL173128NIAID NIH HHS R01 AI029168NIAID NIH HHS R37 AI029168NIGMS NIH HHS R01 GM124104
6 · The paper itself

Abstract

In longitudinal studies, investigators are often interested in understanding how the time since the occurrence of an intermediate event affects a future outcome. The intermediate event is often asymptomatic such that its occurrence is only known to lie in a time interval induced by periodic examinations. We propose a linear regression model that relates the time since the occurrence of the intermediate event to a continuous response at a future time point through a rectified linear unit activation function while formulating the distribution of the time to the occurrence of the intermediate event through the Cox proportional hazards model. We consider nonparametric maximum likelihood estimation with an arbitrary sequence of examination times for each subject. We present an EM algorithm that converges stably for arbitrary datasets. The resulting estimators of regression parameters are consistent, asymptotically normal, and asymptotically efficient. We assess the performance of the proposed methods through extensive simulation studies and provide an application to the Atherosclerosis Risk in Communities Study.

Indexed as

Duration of exposureintermediate eventnonparametric likelihoodproportional hazardsrectified linear unitsemiparametric efficiency

Identifiers

PMID40689020
PMCPMC12272158

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.