ArticleCureus2025
A Rare Case of Seronegative Lupus Nephritis Presenting as Immune Complex Diffuse Glomerulonephritis.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Autoantibody repertoire in lupus nephritis: from pathogenic mechanisms to clinical integration for precision decision-making.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lupus nephritis (LN) is a well-characterized renal manifestation of systemic lupus erythematosus (SLE), typically supported by serologic markers such as antinuclear antibody (ANA) and anti-double stranded deoxyribonucleic acid (anti-dsDNA). However, seronegative presentations remain rare and diagnostically elusive, particularly when renal involvement precedes other systemic features. We report a case of a 31-year-old male with type 1 diabetes who presented with progressive anasarca, dyspnea, and a diffuse non-blanching rash. Laboratory evaluation revealed nephrotic-range proteinuria, hypoalbuminemia, and elevated serum creatinine. Despite strong clinical suspicion, comprehensive autoimmune serologies, including ANA, anti-dsDNA, extractable nuclear antigen (ENA) panel, and anti-neutrophil cytoplasmic antibodies (ANCA), were negative. Renal biopsy demonstrated diffuse proliferative glomerulonephritis with a full house immunofluorescence pattern, including granular capillary wall staining for immunoglobulin G, A, and M (IgG, IgA, and IgM), complement 1q (C1q), and complement 3 (C3). These findings, in the absence of secondary causes such as infection, paraproteinemia, or cryoglobulinemia, supported a diagnosis of seronegative lupus nephritis. The patient was initiated on corticosteroids and mycophenolate mofetil, with resolution of edema and stabilization of renal function. This case highlights the diagnostic significance of renal biopsy in seronegative LN. The presence of a full house immune complex deposition pattern should prompt consideration of LN regardless of serologic status. While rare, seronegative LN underscores the limitations of relying solely on serologies for diagnosis and reinforces the central role of histopathology in complex glomerular disease. In patients presenting with immune complex-mediated glomerulonephritis and absent serologic markers, seronegative lupus nephritis should remain on the differential. Renal biopsy not only establishes diagnosis but also guides timely immunosuppressive therapy critical to preserving renal function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.