ArticleCureus2025
Missed Venous Thromboembolism Prophylaxis in ICU Patients: A Retrospective Cohort Study Using the Medical Information Mart for Intensive Care IV (MIMIC-IV).
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionVenous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, is a preventable complication that significantly contributes to morbidity and mortality in intensive care unit (ICU) patients. Despite established guidelines recommending routine prophylaxis, many ICU patients do not receive the indicated doses.
methodsWe conducted a retrospective cohort study using the Medical Information Mart for Intensive Care IV (MIMIC-IV), a publicly available critical care database. Adult patients with a single ICU admission were stratified by receipt of pharmacologic VTE prophylaxis (subcutaneous heparin or enoxaparin). Primary outcomes were ICU length of stay (LOS) and in-hospital mortality. We performed t-tests, chi-square tests, and multivariable logistic regression, adjusting for age, gender, and emergency admission status.
resultsAmong 65,355 ICU patients, 85.6% received pharmacologic prophylaxis. Patients who missed prophylaxis had significantly shorter ICU LOS (1.80 vs. 3.80 days, p < 0.001) but higher in-hospital mortality (17.1% vs. 11.6%, p < 0.001). Prophylaxis was associated with a 65% reduction in the adjusted odds of in-hospital death (OR: 0.35; 95% CI: 0.34-0.37).
conclusionsMissed VTE prophylaxis in ICU patients was associated with an increased in-hospital mortality. These findings support ICU quality improvement initiatives aimed at standardizing prophylaxis protocols to reduce preventable harm.
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