ArticleCureus2025
Effects of Exercise on Dopamine Expression and Motor Recovery in Hemorrhagic and Ischemic Stroke Rat Models With Comparable Brain Lesions.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Mechanisms of exercise-based rehabilitation following intracerebral hemorrhage: insights from preclinical evidence.Frontiers in pharmacology · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated the differential effects of identical treadmill exercise regimens on motor function recovery, lesion volume, and dopamine expression in rat models of ischemic stroke (ISC) and intracerebral hemorrhage (ICH) with comparable brain injury size and location. Thirty male Wistar rats were divided into five groups: ISC, ICH, sham (SHAM), ISC with exercise (ISC + Ex), and ICH with exercise (ICH + Ex). ISC and ICH lesions were induced in the left striatum using endothelin-1 and bacterial collagenase, respectively. Rats in the exercise groups underwent treadmill running (11 m/min, 30 min/day) from postoperative day 4 to 27. Motor function was assessed using the rotarod test, lesion volume was measured via Nissl staining, and dopamine expression was analyzed using tyrosine hydroxylase (TH) immunohistochemistry. On postoperative day 28, exercise significantly reduced lesion volume in ISC + Ex compared to ISC but had no effect on lesion volume in ICH + Ex. Motor function improved in ISC + Ex but not in ICH + Ex. However, TH expression was significantly higher in the ICH + Ex group than in other groups, suggesting that dopamine contributes to recovery mechanisms after ICH. Treadmill exercise had distinct effects on ISC and ICH recovery. In ISC, exercise improved motor function and reduced lesion volume. In ICH, it enhanced dopamine expression without improving motor function. These findings suggest that rehabilitation strategies should be tailored to stroke type to optimize recovery outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.