ArticleCureus2025
ANCA-Negative Microscopic Polyangiitis With Gastrointestinal and Renal Involvement: A Diagnostic and Therapeutic Challenge.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
We present the case of a 64-year-old male with acute kidney injury (AKI) and gastrointestinal symptoms. Computed tomography (CT) revealed inflammatory changes in the lungs and colon, and push enteroscopy confirmed enteritis. Initially, AKI was attributed to GI losses causing prerenal azotemia, but persistent proteinuria prompted kidney biopsy, confirming anti-neutrophil cytoplasmic antibody (ANCA)-negative microscopic polyangiitis (MPA). While induction immunosuppression was planned, the patient developed necrotizing fasciitis requiring treatment deferral. Renal function ultimately normalized with steroids alone, highlighting the need for individualized therapy in seronegative vasculitis. This case underscores the diagnostic challenge of ANCA-negative MPA and the pivotal role of histopathology and multidisciplinary collaboration.
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