ArticleCureus2025
Epstein-Barr Virus (EBV)-Positive Diffuse Large B-Cell Lymphoma in a Young Patient: A Difficult Diagnosis.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (EBV+DLBCL) was initially hypothesized to occur against a background of age-related immunodeficiency and was classified as EBV-positive DLBCL of the elderly. Subsequent reports of younger patients led to the renaming of the disease. A 17-year-old girl with no significant medical history presented with a left neck mass. Positron emission tomography-CT revealed augmented FDG accumulation in the left neck and multiple FDG accumulations in other lymph nodes, necessitating a biopsy. Histological findings revealed destruction of the follicular structure within the lymph nodes, with some parts exhibiting nodular formation due to fibrosis. Large Hodgkin/Reed-Sternberg (HRS)-like cells intermingled with small lymphocytes and histiocytes were observed. Immunostaining revealed that the HRS-like cells were positive for CD20 and EBER-ISH and negative for CD30 and CD15. The expression of PD-L1 was observed in tumor cells, whereas the cells were mostly negative for c-Myc. The patient was young and exhibited no symptoms indicative of immunodeficiency, thereby supporting the hypothesis of a pathogenesis derived from immune evasion. We focused on the relationship between PD-L1, which is involved in immune evasion mechanisms, and c-Myc, which may directly contribute to the immune escape of tumor B cells.
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