ArticleCureus2025
Extravasation of Intravenous Acyclovir in a Patient With Human Herpesvirus 7 Encephalitis: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Acyclovir is a widely used antiviral agent, but intravenous administration can cause cutaneous adverse reactions, particularly extravasation. We report a rare case of acyclovir extravasation in a 20-year-old female patient with human herpesvirus 7 (HHV-7) encephalitis, who developed immediate vesicular skin lesions at the infusion site. The rapid improvement after drug withdrawal and cold compression favored extravasation over herpes infection progression or drug eruption. Acyclovir's high osmolality and alkalinity contribute to tissue damage. While no standard protocol exists, early detection, infusion discontinuation, aspiration, saline infiltration, cold compression, and hyaluronidase can help minimize injury. This case highlights the importance of prompt recognition and management to prevent complications.
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