Evidence map›Paper›PMID 40688680›Full record

ArticleMaterials today. Bio2025

Inhibition of gastric adenocarcinoma proliferation by WSGC@MS: Role of KEAP1/NRF2 signaling pathway and autophagy regulation.

Dongjian Song, Qiuliang Liu, Zechen Yan, Qi Wang, Meng Su, Hui Zhang, Longyan Shi, Yingzhong Fan, Qian Zhang, Heying Yang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dongjian SongDepartment of Pediatric Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, PR China.
Qiuliang LiuDepartment of Pediatric Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, PR China.
Zechen YanInstitute of Molecular Cancer Surgery, Zhengzhou University, Henan Province Engineering Research Center, Zhengzhou, 450052, Henan, PR China.
Qi WangDepartment of Pediatric Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, PR China.
Meng SuDepartment of Pediatric Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, PR China.
Hui ZhangDepartment of Pediatric Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, PR China.
Longyan ShiDepartment of Pediatric Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, PR China.
Yingzhong FanDepartment of Pediatric Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, PR China.
Qian ZhangDepartment of Pediatric Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, PR China.
Heying YangDepartment of Pediatric Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, PR China.
Da ZhangDepartment of Pediatric Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Porous Magnetic Chitosan Microspheres (MS) serve as effective carriers for targeted drug delivery due to their magnetic properties and biocompatibility. This study investigates the therapeutic potential of WSGC Peptide-loaded porous MS (WSGC@MS) in treating gastric adenocarcinoma by elucidating its mechanism of action in inhibiting cancer cell proliferation. The prepared porous MS was characterized using various techniques, and the physicochemical properties of the nanocomposites were evaluated. In vitro experiments demonstrated that WSGC@MS effectively suppressed the proliferation of gastric adenocarcinoma cells, enhanced apoptosis, and increased cellular uptake and reactive oxygen species production under magnetic field exposure.

Indexed as

AutophagyGastric adenocarcinomaKelch-like ECH-Associated protein 1/nuclear factor erythroid 2-related factor 2 signaling pathwayMagnetic chitosan microspheresNanotechnology treatmentWSGC peptide

Identifiers

PMID40688680
PMCPMC12272921

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.