Evidence map›Paper›PMID 40688670›Full record

ArticleMaterials today. Bio2025

pH-sensitive fibronectin nanogels combined with UTMD for anti-atherosclerosis treatment through anti-inflammatory and antioxidant effects.

Mengjiao Zhang, Xianghao Xiao, Xinyi Li, Xiangyang Shi, Zhaojun Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mengjiao ZhangDepartment of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, PR China.
Xianghao XiaoCollege of Biological Science & Medical Engineering, Donghua University, Shanghai, 201620, PR China.
Xinyi LiDepartment of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, PR China.
Xiangyang ShiCollege of Biological Science & Medical Engineering, Donghua University, Shanghai, 201620, PR China.
Zhaojun LiDepartment of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The reactive oxygen species (ROS) and inflammatory factors secreted by macrophages play pivotal roles in all stages of atherosclerotic progression. Achieving targeted plaque localization while simultaneously reducing ROS levels to exert both anti-inflammatory and antioxidant effects remains a significant challenge. In this work, we developed a pH sensitive curcumin (Cur)-loaded fibronectin (FN) nanogels, combined with ultrasound-targeted microbubble destruction (UTMD) to enhance therapeutic efficacy via cavitation effects. The FN/FBA-PEG-FBA@Cur (denoted as FNC) nanogels demonstrated a targeted effect on atherosclerosis sites, attributed to the strong affinity between the RGD sequence on FN and the integrins highly expressed on the surface of plaque cells. Moreover, the Schiff base linkages in the nanogels respond to the acidic microenvironment within atherosclerosis plaques, leading to the controlled Cur release, which enable anti-inflammatory and antioxidant activity to attenuate plaque progression. Both

Indexed as

AtherosclerosisFibronectinNanogelsUltrasound-targeted microbubble destruction

Identifiers

PMID40688670
PMCPMC12274839

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.