ArticleMaterials today. Bio2025
Self-powered intracellular nanogenerator attenuates inflammatory osteolysis through mitochondrial MRS2/Mg
Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Magnesium Enhances Immune Clearance of P. gingivalis in Macrophages by Suppressing MCU-Mediated Mitochondrial Calcium Overload.Cell proliferation · 2026Article
- Review
- Exosome-enabled bone defect repair: mechanistic foundations, bioengineered delivery, and artificial intelligence-driven translation.Journal of nanobiotechnology · 2026Review
- Harnessing piezoelectricity for bone tissue engineering: recapitulating the electrophysiological microenvironment through smart biomaterials.Frontiers in bioengineering and biotechnology · 2026Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammatory bone resorption is present in common oral and maxillofacial diseases. Macrophages play a crucial role in the inflammatory process of bone. It has been shown that M1 macrophages cause bone homeostasis and bone resorption disorders, and M2 macrophage-related cytokines inhibit osteoclast generation. To inhibit inflammatory bone resorption, a method that promotes M2 polarization and inhibits M1 polarization and osteoclastogenesis should be found. Studies have found that the mitochondrial membrane potential of macrophage increases during M2 differentiation, but decreases during M1 differentiation and osteoclast differentiation. Therefore, we hypothesized that it might be possible to use electric fields to regulate macrophage polarization and osteoclast differentiation. Piezoelectric materials have been shown to be a safe and effective material that can form piezoelectric potentials, but the role of piezoelectric nanomaterials and nano-electric fields in macrophage M2 differentiation and osteoclastogenesis remains to be investigated. Thus, in this study, polarized piezoelectric nanomaterial BaTiO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.