Evidence map›Paper›PMID 40688655›Full record

ArticleMaterials today. Bio2025

Bilayer book- like decellularized extracellular matrix scaffold with bioactive coatings for rotator cuff repair.

Jintao Li, Haolin Ke, Dianxuan Wu, Yan Shao, Zhicheng Wen, Shaozi Zhong, Xiangcheng Lei, Jihua Li, Denghui Xie, Chun Zeng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jintao LiDepartment of Sports Medicine, Center for Orthopedic Surgery, Orthopedic Hospital of Guangdong Province, The Third Affiliated Hospital, Southern Medical University, Guangzhou, 510630, PR China.
Haolin KeDepartment of Sports Medicine, Center for Orthopedic Surgery, Orthopedic Hospital of Guangdong Province, The Third Affiliated Hospital, Southern Medical University, Guangzhou, 510630, PR China.
Dianxuan WuDepartment of Sports Medicine, Center for Orthopedic Surgery, Orthopedic Hospital of Guangdong Province, The Third Affiliated Hospital, Southern Medical University, Guangzhou, 510630, PR China.
Yan ShaoDepartment of Sports Medicine, Center for Orthopedic Surgery, Orthopedic Hospital of Guangdong Province, The Third Affiliated Hospital, Southern Medical University, Guangzhou, 510630, PR China.
Zhicheng WenDepartment of Sports Medicine, Center for Orthopedic Surgery, Orthopedic Hospital of Guangdong Province, The Third Affiliated Hospital, Southern Medical University, Guangzhou, 510630, PR China.
Shaozi ZhongDepartment of Sports Medicine, Center for Orthopedic Surgery, Orthopedic Hospital of Guangdong Province, The Third Affiliated Hospital, Southern Medical University, Guangzhou, 510630, PR China.
Xiangcheng LeiCentre for Translational Medicine Research & Development, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, PR China.
Jihua LiDepartment of Sports Medicine, Center for Orthopedic Surgery, Orthopedic Hospital of Guangdong Province, The Third Affiliated Hospital, Southern Medical University, Guangzhou, 510630, PR China.
Denghui XieDepartment of Sports Medicine, Center for Orthopedic Surgery, Orthopedic Hospital of Guangdong Province, The Third Affiliated Hospital, Southern Medical University, Guangzhou, 510630, PR China.
Chun ZengDepartment of Sports Medicine, Center for Orthopedic Surgery, Orthopedic Hospital of Guangdong Province, The Third Affiliated Hospital, Southern Medical University, Guangzhou, 510630, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Repairing the tendon-bone interface after rotator cuff injury and regulating the local immune microenvironment present significant clinical challenges, necessitating the development of bioactive materials capable of simultaneous interface repair and inflammation modulation. In this study, we developed a book-like scaffold (dtECM-TAZn/Mg) with bilayers of bioactive coatings to target the bone microenvironment and promote rotator cuff repair. Fabricated from decellularized tendon extracellular matrix (dtECM) to preserve native collagen fiber alignment, the scaffold underwent covalent cross-linking of a tannic acid (TA) coating onto its surface. Subsequent incorporation of Zn

Indexed as

Bioactive coatingsBone microenvironmentDecellularized tendon extracellular matrixMetal-polyphenol networksRotator cuff injury

Identifiers

PMID40688655
PMCPMC12272927

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.