ReviewOncology letters2025
Novel therapeutic strategies for non-small cell lung cancer: Combination therapies with immune checkpoint inhibitors (Review).
Review in Oncology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Enhancing Chemotherapeutic Efficacy in Lung Cancer Cells Through Synergistic Targeting of the PI3K/AKT Pathway with Small Molecule Inhibitors.International journal of molecular sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The treatment of non-small cell lung cancer (NSCLC) has been notably improved by the use of immune checkpoint inhibitors (ICIs). Although ICIs have been authorized by the United States Food and Drug Administration for the clinical treatment of NSCLC, concerns remain regarding resistance and adverse reactions. Chemotherapy, targeted therapy and other immunotherapies for cancer have the potential to impact cancer immunity, thereby boosting the ability of the body to kill the tumor cells. This provides preliminary evidence for combined therapy, which has been reported to be effective in numerous clinical trials, resulting in the approval of ICIs for use in combination with chemotherapy. Ongoing studies concentrate on novel approaches that can enhance immune responses against tumors through combined strategies. The present review primarily outlines the key mechanisms of combined treatment and the strategies for combining ICIs in NSCLC, demonstrating the viability of combined therapy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.