ArticleHardwareX2025
Open-source tubing-free impeller pump platform for controlled recirculating fluid flow for microfluidics and organs-on-chip.
Article in HardwareX, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Immune Cell Responses to Fluid Shear: Overview and Design Considerations forCurrent opinion in biomedical engineering · 2026Article
- Opportunities and challenges for analytical chemists: organ-on-chip devices as new approach methods (NAMs) for identifying potential toxins.The Analyst · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Fluid flow is utilized in many microscale technologies, including microfluidic chemical reactors, diagnostics, and organs-on-chip (OOCs). In particular, OOCs may rely on fluid flow for nutrient delivery, cellular communication, and application of shear stress. In order for microscale flow systems to be readily adopted by non-experts, a tubing-free, user-friendly pump would be useful, particularly one that is simple to use, affordable, and compatible with cell culture incubators. To address these needs, here we share the design and fabrication of an impeller pump platform that provides recirculating fluid flow through a microfluidic loop without the need for tubing connections. Flow is driven by rotating a magnetic stir bar or 3D-printed impeller in a pump well, using magnets mounted on a DC motor. The DC motors used produce negligible heat output in a compact system, making it compatible with cell culture incubators. The pump platform accommodates user-defined microfluidic or OOC device geometries, which may be easily customized by 3D printing. Furthermore, the system is easily assembled from low-cost materials and simple circuitry by someone with no prior training. We demonstrate the ability of the platform to drive recirculating fluid flow in a microfluidic device at well-characterized flow velocities ranging from µm/s to mm/s for use with microfluidic technologies. Though designed with OOCs in mind, we envision that this platform will enable users from ranging disciplines to incorporate fluid flow in customized microscale technologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.