Evidence map›Paper›PMID 40688507›Full record

ReviewBiochemistry and biophysics reports2025

Synergistic roles of NFATc1 and c-Jun in immunomodulation.

Bo Cao, Renqian Wei

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biochemistry and biophysics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Bo CaoDepartment of Orthopedics Center, Affiliated Qingyuan Hospital, The Sixth Clinical Medical School, Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, China.
Renqian WeiDepartment of Orthopedics Center, Affiliated Qingyuan Hospital, The Sixth Clinical Medical School, Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The immune system relies on precise regulatory mechanisms, with transcription factors being central to modulating immune responses. NFATc1 and c-Jun are key transcription factors that influence both adaptive and innate immunity. This review provides a comprehensive examination of the individual and synergistic roles of NFATc1 and c-Jun in immune regulation. We delve into their molecular mechanisms, regulatory pathways, and the latest experimental approaches used to study these interactions. Furthermore, we explore the therapeutic potential of targeting these transcription factors, highlighting their clinical implications in treating immune-related diseases. This analysis underscores the critical importance of NFATc1 and c-Jun, paving the way for innovative and better therapeutic strategies and future research in immune regulation research.

Indexed as

AP-1 complexc-JunImmune regulationInflammatory responseNFATc1Synergistic interactionTranscription factors

Identifiers

PMID40688507
PMCPMC12272594

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.