ReviewJournal of orthopaedics2025
Outcomes of total knee arthroplasty in people with diabetes: An overview of systematic reviews and meta-analysis.
Review in Journal of orthopaedics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Article
- Perioperative outcomes of total and unicompartmental knee arthroplasty in patients with Type 2 diabetes mellitus: A propensity score-matched analysis.Journal of experimental orthopaedics · 2026Article
- Impact of Glucagon-Like Peptide-1 Receptor Agonists on Knee Arthroplasty Outcomes.Indian journal of orthopaedics · 2026Review
- A narrative review of clinical research on knee osteoarthritis in 2025.Annals of joint · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and aims: Total knee arthroplasty (TKA) in people with diabetes is associated with increased risks of postoperative complications. This review evaluates how diabetes influences complication rates and overall outcomes following TKA. Methods: An overview of systematic reviews and meta-analyses was conducted, with a comprehensive search performed across databases including PubMed, Scopus, Web of Science, and the Cochrane Library. The protocol was registered on PROSPERO on December 12, 2024. Results: People with diabetes undergoing TKA face a 43 % higher risk of periprosthetic joint infection (PJI) and are 45 % more likely to experience deep vein thrombosis (DVT). The rates of hospital readmissions were significantly higher, showing a 28 % increased likelihood. Subpopulations with insulin-treated diabetes exhibited a 60 % greater incidence of perioperative adverse events. Notably, people with diabetes undergoing TKA had significantly higher odds of developing infection (OR 1.97, 95 % CI 1.48-2.61, p = 0.004) and deep PJI (OR 2.10, 95 % CI 1.49-2.95, p < 0.001). Significantly higher odds of DVT were observed in people with diabetes (OR 1.43, 95 % CI 1.23-1.66, p < 0.0000). Inadequate perioperative glycemic control was identified as a modifiable risk factor, although definitions varied widely across studies. Conclusions: The presence of diabetes significantly impacts post-TKA outcomes, leading to higher complication rates and negatively affecting physical function and quality of life. Further rigorous studies are needed to establish standardized definitions for glycemic control and to investigate mechanisms contributing to increased risks, facilitating improved preoperative risk stratification and management strategies for diabetic patients undergoing TKA.
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